Organoelement Compounds
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ChemInform Abstract: cis-Diamminediaquaplatinum(II) Selectivity for GpG: Influence of the Adjacent Base on the First Platination Step.
First published: November 29, 1988
Abstract
Rate constants for the first platination of XpG and GpX dinucleotides (X: G, A, C) by cis-(Pt(NH3)2(OH2)2)2+ are measured, analyzed, and interpreted by molecular mechanics modeling of the pentacoordinated reaction intermediate.
ChemInform Abstract
Rate constants for the first platination of XpG and GpX dinucleotides (X: G, A, C) by cis-(Pt(NH3)2(OH2)2)2+ are measured, analyzed, and interpreted by molecular mechanics modeling of the pentacoordinated reaction intermediate. The second guanine in GpG accelerates the first platination, a 5'-guanine more than a 3'-guanine.
