ChemInform Abstract: Interaction of Metal Ions with 6-Oxopurine Nucleotides. Part 2. X-Ray Structures of Ternary Nickel(II) Complexes with 2′-Deoxyguanosine 5′-Monophosphate or Guanosine 5′-Monophosphate.

ChemInform Abstract

The ternary Ni(II) complexes (I) and (II) are prepared from (Ni(en)(OH2)4)X2 (X: NO₃, 1/2 SO₄) and disodium salts of the corresponding nucleotide monophosphates. They are characterized by X-ray structure analysis. Both compounds crystallize in the space group C2221, with Z=4. An interesting feature of the deoxyribonucleotide complex (I) is that en is not totally labilized from the metal center on nucleotide coordination as observed in corresponding ribonucleotide complexes. Apart from extensive intra- and intermolecular hydrogen bonding, the structures are stabilized by significant intracomplex base-base and base-sugar interactions. The nucleotides, in both complexes N-7 coordinated, have an anti base, C(2')-endo sugar pucker, and gauche-gauche conformation about the C(4')-C(5') bond.