Volume 19, Issue 4
Isocyclic Compounds
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ChemInform Abstract: Rapid and Large-Scale Synthesis of Sulfonyl Substituted Propanones.

R. DAVIS

R. DAVIS

Inst. Org. Chem., Syntex Discovery Res., Palo Alto, CA 94304, USA

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First published: January 26, 1988

Abstract

Coupling of the thiols (I) with chloroacetone (II) in the presence of sodium hydroxide and KHSO5 (oxone) yields the sulfonylpropanones (III).

ChemInform Abstract

Coupling of the thiols (I) with chloroacetone (II) in the presence of sodium hydroxide and KHSO5 (oxone) yields the sulfonylpropanones (III). The reaction can easily be monitored by pH measurements.

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