Preparative Organic Chemistry
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ChemInform Abstract: An Extension of the Hurtley Reaction to Heterocyclic Nucleophiles.
First published: January 26, 1988
Abstract
The N-methylisoquinolinedione (I) is coupled with the bromoarenes (II) in the presence of sodium ethoxide and copper powder or copper(I) bromide to produce the 4-arylisoquinolinediones (III).
ChemInform Abstract
The N-methylisoquinolinedione (I) is coupled with the bromoarenes (II) in the presence of sodium ethoxide and copper powder or copper(I) bromide to produce the 4-arylisoquinolinediones (III). This method, developed by Hurtley, is based on the activation of the reactants due to intermediate formation of copper complexes.
