Preparative Organic Chemistry
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ChemInform Abstract: Reduction of gem-Dibromocyclopropanes with Dialkyl Phosphonate and Amine.
First published: January 26, 1988
Abstract
The dialkyl phosphonates (II) are employed in the reduction debromination of the bicyclic geminal dibromide (I) to give mixtures of the endo- and exo-bromides (III).
ChemInform Abstract
The dialkyl phosphonates (II) are employed in the reduction debromination of the bicyclic geminal dibromide (I) to give mixtures of the endo- and exo-bromides (III). The best results are obtained using diethyl phosphonate (IIb) in the presence of triethylamine. The influence of other bases is also tested. Treatment of the cyclopropyl dibromides (IV) and (VI) with (IIb)/Et3N yields the monobromides(V) or (VII).
