Preparative Organic Chemistry
Full Access
ChemInform Abstract: Asymmetric Reduction of Aromatic Ketones and Asymmetric Hydroboration of 2-Phenyl-1-alkenes with the Reagent Prepared from Borane - Methyl Sulfide and (1S,2S)-(+)-2-Amino-3-methoxy-1-phenyl-1-propanol.
First published: January 12, 1988
Abstract
The chiral amino alcohol (I) is treated with the borane - dimethyl sulfide complex to form a reagent which is used for the asymmetric reduction of the aryl alkyl ketones (IIa) - (IIc) and tert-butyl methyl ketone (IId), yielding the optically active secondary alcohols (III).
ChemInform Abstract
The chiral amino alcohol (I) is treated with the borane - dimethyl sulfide complex to form a reagent which is used for the asymmetric reduction of the aryl alkyl ketones (IIa) - (IIc) and tert-butyl methyl ketone (IId), yielding the optically active secondary alcohols (III). Using the same reagent, the 2-phenyl-1-alkenes (IV) are hydroborated to produce the 2-phenyl-1-alkanols (V).
