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ChemInform Abstract: Total Synthesis of 5(S),20- and 15(S),20-Dihydroxyeicosatetraenoic Acid and 5(S),6(R)-Epoxy-20-hydroxy- and 14(R),15(S)-Epoxy-20-hydroxyeicosatrienoic Acid.
First published: September 22, 1987
Abstract
The aldehyde (II) is transformed into the epoxy aldehyde (IV) which undergoes a Wittig reaction with the phosphorane (V).
ChemInform Abstract
The aldehyde (II) is transformed into the epoxy aldehyde (IV) which undergoes a Wittig reaction with the phosphorane (V). Subsequent desilylation and hydrolysis yield the acid (VI). The acids (VII) - (IX) are also prepared from (II) in a similar manner.
