Heterocyclic Compounds
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ChemInform Abstract: Asymmetric α-Amidoalkylation. Synthesis of α-Substituted Piperidines of High Enantiomeric Purity.
First published: September 22, 1987
Abstract
The chiral enamide (I) is converted into the iminium salt (III) which reacts with the silyl enol ethers (IV), yielding the diastereomeric amidoalkylation products (V) and (VI).
ChemInform Abstract
The chiral enamide (I) is converted into the iminium salt (III) which reacts with the silyl enol ethers (IV), yielding the diastereomeric amidoalkylation products (V) and (VI). The ketones (VIa) and (VIc) are transformed into (+)-sedamine (VII) and the piperidines (IX) and (X).
