Isocyclic Compounds
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ChemInform Abstract: An Efficient Synthesis of 2-(3,4-Dimethoxyphenyl)succinimide.
First published: September 22, 1987
Abstract
The arylacetonitrile (I) is coupled with the bromoacetate (II) and then saponified to yield the 3-aryl-3-cyanopropanoic acid (III).
ChemInform Abstract
The arylacetonitrile (I) is coupled with the bromoacetate (II) and then saponified to yield the 3-aryl-3-cyanopropanoic acid (III). Hydrolysis of the nitrile group leads to the formation of the arylsuccinic acid (IV). This undergoes ring closure on heating with ammonia, producing the arylpyrrolidinedione (V) which is a precursor of various compounds with central dopaminergic activity.
