Heterocyclic Compounds
Full Access
ChemInform Abstract: Efficient Synthetic Method for Ethyl (+)-(2S,3S)-3-((S)-3-Methyl-1-(3- methylbutylcarbamoyl)butylcarbamoyl)-2-oxiranecarboxylate (EST), a New Inhibitor of Cysteine Proteinases.
First published: September 8, 1987
Abstract
The title compound (VI) is synthesized from the optically pure oxiranedicarboxylic acid (I) as shown in the reaction scheme.
ChemInform Abstract
The title compound (VI) is synthesized from the optically pure oxiranedicarboxylic acid (I) as shown in the reaction scheme. The key step is the amidation of the activated ester (IV) with L-leucine isoamylamide (V).
