Heterocyclic Compounds
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ChemInform Abstract: Nucleophilic Additions to Thionolactones. New Synthetic Technology for the Construction of Medium- and Large-Ring Ethers.
First published: September 1, 1987
Abstract
Thionolactones such as (I) can be conveniently transformed to substituted cyclic ethers such as (V) via addition products such as (IV) which are subsequently desulfurized to (V).
ChemInform Abstract
Thionolactones such as (I) can be conveniently transformed to substituted cyclic ethers such as (V) via addition products such as (IV) which are subsequently desulfurized to (V). Similarly, the compounds (VI)-(IX) are prepared in high yields. The convenient and clean generation of the free radical species (XI) allows the construction of the complex polycyclic systems (XII) and (XIII). Furthermore,an application of the described technology provides a short and efficient total synthesis of (±)-lauthisan (XVI) from the precursor (XV).
