ChemInform Abstract: Synthesis and Antirhinovirus Activity of Halogen-Substituted Isoflavenes and Isoflavans.

ChemInform Abstract

The isoflavenes (III) are synthesized as shown in the scheme. Whereas reduction of the chlorides (IIIa)-(IIIc) yields the desired racemic isoflavans (IV), the bromides (IIId) do not react under these conditions. The activity of (III) and (IV) against rhinovirus 1B is tested and compared with that of the known antiviral compound 4',6-dichloroflavan. The results are tabulated and the structure-activity relationship is discussed.