Heterocyclic Compounds
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ChemInform Abstract: Observations on the Reactions of Isocyanoacetate Esters with Isothiocyanates and Isocyanates.
First published: September 1, 1987
Abstract
Cyclization of the thiocyanates (II) and (VI) with the isocyanoacetate (I) gives the thiazoles (III) and (VIIa); the unstable thiol (IV) which is also produced is oxidized, forming the disulfide (V).
ChemInform Abstract
Cyclization of the thiocyanates (II) and (VI) with the isocyanoacetate (I) gives the thiazoles (III) and (VIIa); the unstable thiol (IV) which is also produced is oxidized, forming the disulfide (V). The acid (VIIb) is obtained from (VI) and (I) in the presence of potassium tert- butoxide. Reaction of the lithium salt of the isocyanide (VIII) with benzyl isocyanate (IX) leads to the formation of the oxazole (X).
