Preparative Organic Chemistry
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ChemInform Abstract: Preparation of Hindered Lithium Amide Bases and Rates of Their Reaction with Ether Solvents.
First published: September 1, 1987
Abstract
The sterically hindered amines (I) are completely converted to the corresponding lithium amides (II) by reaction with butyllithium in the presence of equimolar amounts of tetramethylethyleneamine (TMEDA).
ChemInform Abstract
The sterically hindered amines (I) are completely converted to the corresponding lithium amides (II) by reaction with butyllithium in the presence of equimolar amounts of tetramethylethyleneamine (TMEDA). Without TMEDA, the reaction proceeds very slowly. It is shown that the lithium amides (II) have only limited stability in solvents such as diethyl ether or tetrahydrofuran.
