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ChemInform Abstract: Synthesis of 1,4-Diaminocyclitol Antibiotics. Part 2. Synthesis of 7′-Propylfortimicin A.
First published: June 16, 1987
Abstract
The hexopyranoside (I) is converted to the decopyranoside (V), which is hydrogenated to give the β-L-lyxo-decopyranoside (VI).
ChemInform Abstract
The hexopyranoside (I) is converted to the decopyranoside (V), which is hydrogenated to give the β-L-lyxo-decopyranoside (VI). It is transformed to the dinitrophenyl protected derivative (VIII), which undergoes condensation with the aglycon (IX) (prepared in 3 steps from fortimicin B) to give (X). The following deprotection steps lead to the title compound (XI), whose antimicrobial activity is tested.
