Heterocyclic Compounds
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ChemInform Abstract: Anthrapyrazole Anticancer Agents. Synthesis and Structure-Activity Relationships Against Murine Leukemias.
First published: June 16, 1987
Abstract
The dichloroanthraquinones (I) and (VI) cyclize with the hydrazines (II) to give the chloroanthrapyrazoles (III) and (VII) respectively which are converted to the amino derivatives (V) and (IX) by reaction with the amines (IV) and (VIII).
ChemInform Abstract
The dichloroanthraquinones (I) and (VI) cyclize with the hydrazines (II) to give the chloroanthrapyrazoles (III) and (VII) respectively which are converted to the amino derivatives (V) and (IX) by reaction with the amines (IV) and (VIII). The antitumor activities of the compounds (V) and (IX) against L1210 leukemia in vitro and P388 leukemia in vivo are studied. (Comparison with doxorubicin and mitoxantrone, IR-, UV-, 1H-NMR-, pKa-data).
