Preparative Organic Chemistry
Full Access
ChemInform Abstract: Synthesis of Chiral Aminophosphinephosphinites. Application for Asymmetric Catalytic Reductions.
First published: June 9, 1987
Abstract
The chiral aminophosphinephosphinite ligands (V) - (VIII) are prepared by the reaction of chlorophosphine (IV) with optically active amino alcohols such as (III), which are obtained from the natural α-amino acids (I) by reduction.
ChemInform Abstract
The chiral aminophosphinephosphinite ligands (V) - (VIII) are prepared by the reaction of chlorophosphine (IV) with optically active amino alcohols such as (III), which are obtained from the natural α-amino acids (I) by reduction. The cationic rhodium complexes (X) of these compounds are applied as catalysts for the homogeneous enantioselective hydrogenation of the dehydroamino acids (IX) and for the asymmetric reduction of the α-keto lactone (XII). (1H-, 13C-, 31P-NMR-, opt. rotations).
