Volume 18, Issue 20
Natural Products
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ChemInform Abstract: Enantioselective Synthesis of L-Threonine.

M. SOUKUP

M. SOUKUP

Zent. Forschungseinheiten, F. Hoffmann-La Roche&Co. AG, CH-4002 Basel

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B. WIPF

B. WIPF

Zent. Forschungseinheiten, F. Hoffmann-La Roche&Co. AG, CH-4002 Basel

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E. HOCHULI

E. HOCHULI

Zent. Forschungseinheiten, F. Hoffmann-La Roche&Co. AG, CH-4002 Basel

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H. G. W. LEUENBERGER

H. G. W. LEUENBERGER

Zent. Forschungseinheiten, F. Hoffmann-La Roche&Co. AG, CH-4002 Basel

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First published: May 19, 1987

Abstract

The racemic amido butyrate (Ic) prepared from the oxoester (Ia) via the oxime (Ib) is transformed to the enantiomeric optically active alcohols (IIa)/(IIb) by microbiological reduction.

ChemInform Abstract

The racemic amido butyrate (Ic) prepared from the oxoester (Ia) via the oxime (Ib) is transformed to the enantiomeric optically active alcohols (IIa)/(IIb) by microbiological reduction. The mixture (IIa)/(IIb) can be converted to the title compound (VI) by slightly modified known methods using a one-pot procedure.

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