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ChemInform Abstract: Chemical Studies of 10-Deacetyl Baccatin III. Hemisynthesis of Taxol Derivatives.
First published: January 13, 1987
Abstract
The selective protection of the hydroxyl functions of 10-deacetyl baccatin III (compound (III)) to give either (I) or (IV) opens the way for the functionalization of the 13-OH group to afford (VI), (IX), (X) and (XI).
ChemInform Abstract
The selective protection of the hydroxyl functions of 10-deacetyl baccatin III (compound (III)) to give either (I) or (IV) opens the way for the functionalization of the 13-OH group to afford (VI), (IX), (X) and (XI). Further analogues (XIId)-(XIIf) of taxol (XIIa) are obtained similarly from baccatin III (compound (XIIb)) via the protected intermediate (XIIc) (yields given in mg).
