ChemInform Abstract: The Synthesis of Substituted ZH-12-Benzothiazines 1,1-Dioxides.
Abstract
The benzothiazolinone derivatives (I) are rearranged by bases to yield the benzothiazine compounds (II), which are N-alkylated to give the derivatives (III).
ChemInform Abstract
The benzothiazolinone derivatives (I) are rearranged by bases to yield the benzothiazine compounds (II), which are N-alkylated to give the derivatives (III). Aminolysis of the ester (IIIb) by Z-aminopyridine or by 3-amino-5-methylisoxazole yields the antiin- ?ammatory drugs piroxicam (IV) or isoxicam (V).