Volume 17, Issue 40
Heterocyclic Compounds
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ChemInform Abstract: The Synthesis of Substituted ZH-12-Benzothiazines 1,1-Dioxides.

First published: October 7, 1986

Abstract

The benzothiazolinone derivatives (I) are rearranged by bases to yield the benzothiazine compounds (II), which are N-alkylated to give the derivatives (III).

ChemInform Abstract

The benzothiazolinone derivatives (I) are rearranged by bases to yield the benzothiazine compounds (II), which are N-alkylated to give the derivatives (III). Aminolysis of the ester (IIIb) by Z-aminopyridine or by 3-amino-5-methylisoxazole yields the antiin- ?ammatory drugs piroxicam (IV) or isoxicam (V).

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