Organoelement Compounds
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ChemInform Abstract: Sila-Pharmaca. Part 33. Synthesis and Properties of the Selective Antimuscarinic Agent Cyclohexylphenyl(3-piperidinopropyl)silanol.
First published: February 25, 1986
Abstract
Starting with the trimethoxysilane (I) the silanol (V) is obtained by the four reaction steps in the scheme and isolated as the hydrochloride (total yield about 45%).
ChemInform Abstract
Starting with the trimethoxysilane (I) the silanol (V) is obtained by the four reaction steps in the scheme and isolated as the hydrochloride (total yield about 45%). Because of its high pharmacological selectivity (V) has become a reference drug in experimental pharmacology for the differentiation of myscarinic receptors.
