Preparation and Characterization of Taxifolin Form II by Antisolvent Recrystallization
Weiwei Wu
Northeast Forestry University, Ministry of Education, Key Laboratory of Saline-Alkali Vegetation Ecology Restoration in Oil Field (SAVER), Alkali Soil Natural Environmental Science Center (ASNESC), Harbin Hexing Road, 150040 Harbin, Heilongjiang, China
Search for more papers by this authorLingling Wang
Northeast Forestry University, Ministry of Education, Key Laboratory of Forest Plant Ecology, Hexing Road 26, 150040 Harbin, Heilongjiang, China
Search for more papers by this authorLi Wang
Northeast Forestry University, Ministry of Education, Key Laboratory of Forest Plant Ecology, Hexing Road 26, 150040 Harbin, Heilongjiang, China
Search for more papers by this authorYuangang Zu
Northeast Forestry University, Ministry of Education, Key Laboratory of Forest Plant Ecology, Hexing Road 26, 150040 Harbin, Heilongjiang, China
Search for more papers by this authorLu Wang
Northeast Forestry University, Ministry of Education, Key Laboratory of Forest Plant Ecology, Hexing Road 26, 150040 Harbin, Heilongjiang, China
Search for more papers by this authorYin Zhang
Northeast Forestry University, Ministry of Education, Key Laboratory of Forest Plant Ecology, Hexing Road 26, 150040 Harbin, Heilongjiang, China
Search for more papers by this authorCorresponding Author
Xiuhua Zhao
Northeast Forestry University, Ministry of Education, Key Laboratory of Forest Plant Ecology, Hexing Road 26, 150040 Harbin, Heilongjiang, China
Correspondence: Xiuhua Zhao ([email protected]), Northeast Forestry University, Ministry of Education, Key Laboratory of Forest Plant Ecology, Hexing Road 26, Harbin 150040, Heilongjiang, China.Search for more papers by this authorWeiwei Wu
Northeast Forestry University, Ministry of Education, Key Laboratory of Saline-Alkali Vegetation Ecology Restoration in Oil Field (SAVER), Alkali Soil Natural Environmental Science Center (ASNESC), Harbin Hexing Road, 150040 Harbin, Heilongjiang, China
Search for more papers by this authorLingling Wang
Northeast Forestry University, Ministry of Education, Key Laboratory of Forest Plant Ecology, Hexing Road 26, 150040 Harbin, Heilongjiang, China
Search for more papers by this authorLi Wang
Northeast Forestry University, Ministry of Education, Key Laboratory of Forest Plant Ecology, Hexing Road 26, 150040 Harbin, Heilongjiang, China
Search for more papers by this authorYuangang Zu
Northeast Forestry University, Ministry of Education, Key Laboratory of Forest Plant Ecology, Hexing Road 26, 150040 Harbin, Heilongjiang, China
Search for more papers by this authorLu Wang
Northeast Forestry University, Ministry of Education, Key Laboratory of Forest Plant Ecology, Hexing Road 26, 150040 Harbin, Heilongjiang, China
Search for more papers by this authorYin Zhang
Northeast Forestry University, Ministry of Education, Key Laboratory of Forest Plant Ecology, Hexing Road 26, 150040 Harbin, Heilongjiang, China
Search for more papers by this authorCorresponding Author
Xiuhua Zhao
Northeast Forestry University, Ministry of Education, Key Laboratory of Forest Plant Ecology, Hexing Road 26, 150040 Harbin, Heilongjiang, China
Correspondence: Xiuhua Zhao ([email protected]), Northeast Forestry University, Ministry of Education, Key Laboratory of Forest Plant Ecology, Hexing Road 26, Harbin 150040, Heilongjiang, China.Search for more papers by this authorAbstract
To improve the aqueous solubility and dissolution rate of taxifolin, taxifolin form II was successfully prepared through antisolvent recrystallization, in which 1-butyl-3-methylimidazolium tetrafluoroborate and dichloromethane were used as solvent and antisolvent, respectively. The properties of taxifolin form II were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, differential scanning calorimetry, solid-state NMR spectroscopy, the dissolving capability test, and the bioavailability test. The chemical structure of taxifolin form II was not changed, but its morphology and crystalline structure changed during the recrystallization process. Moreover, taxifolin form II showed higher solubility, faster dissolution rate, and better bioavailability than taxifolin form I.
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