Obesity is associated with acute kidney injury in ST-segment-elevation myocardial infarction undergoing percutaneous coronary intervention: A national representative cohort study
Congyan Ye MD
Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, China
Search for more papers by this authorXueping Ma MD
Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, China
Institute of Cardiovascular Medicine, General Hospital of Ningxia Medical University, Yinchuan, China
Department of Cardiology, General Hospital of Ningxia Medical University, Ningxia Medical University, Yinchuan, China
Search for more papers by this authorBo Shi MD
Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, China
Search for more papers by this authorRui Yan MD
Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, China
Search for more papers by this authorShizhe Fu MD
Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, China
Search for more papers by this authorKairu Wang MD
Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, China
Search for more papers by this authorCorresponding Author
Shaobin Jia PhD
Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, China
Institute of Cardiovascular Medicine, General Hospital of Ningxia Medical University, Yinchuan, China
Department of Cardiology, General Hospital of Ningxia Medical University, Ningxia Medical University, Yinchuan, China
Correspondence Guangzhi Cong, PhD, Ru Yan, MD, and Shaobin Jia, PhD, Department of Cardiovascular Medicine, General Hospital of Ningxia Medical University, Institute of Cardiology, Ningxia Medical University, 804 Shengli St, Xinqing, Yinchuan, Ningxia, China.
Email: [email protected], [email protected] and [email protected]
Search for more papers by this authorCorresponding Author
Ru Yan MD
Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, China
Institute of Cardiovascular Medicine, General Hospital of Ningxia Medical University, Yinchuan, China
Department of Cardiology, General Hospital of Ningxia Medical University, Ningxia Medical University, Yinchuan, China
Correspondence Guangzhi Cong, PhD, Ru Yan, MD, and Shaobin Jia, PhD, Department of Cardiovascular Medicine, General Hospital of Ningxia Medical University, Institute of Cardiology, Ningxia Medical University, 804 Shengli St, Xinqing, Yinchuan, Ningxia, China.
Email: [email protected], [email protected] and [email protected]
Search for more papers by this authorCorresponding Author
Guangzhi Cong PhD
Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, China
Institute of Cardiovascular Medicine, General Hospital of Ningxia Medical University, Yinchuan, China
Department of Cardiology, General Hospital of Ningxia Medical University, Ningxia Medical University, Yinchuan, China
Correspondence Guangzhi Cong, PhD, Ru Yan, MD, and Shaobin Jia, PhD, Department of Cardiovascular Medicine, General Hospital of Ningxia Medical University, Institute of Cardiology, Ningxia Medical University, 804 Shengli St, Xinqing, Yinchuan, Ningxia, China.
Email: [email protected], [email protected] and [email protected]
Search for more papers by this authorCongyan Ye MD
Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, China
Search for more papers by this authorXueping Ma MD
Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, China
Institute of Cardiovascular Medicine, General Hospital of Ningxia Medical University, Yinchuan, China
Department of Cardiology, General Hospital of Ningxia Medical University, Ningxia Medical University, Yinchuan, China
Search for more papers by this authorBo Shi MD
Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, China
Search for more papers by this authorRui Yan MD
Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, China
Search for more papers by this authorShizhe Fu MD
Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, China
Search for more papers by this authorKairu Wang MD
Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, China
Search for more papers by this authorCorresponding Author
Shaobin Jia PhD
Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, China
Institute of Cardiovascular Medicine, General Hospital of Ningxia Medical University, Yinchuan, China
Department of Cardiology, General Hospital of Ningxia Medical University, Ningxia Medical University, Yinchuan, China
Correspondence Guangzhi Cong, PhD, Ru Yan, MD, and Shaobin Jia, PhD, Department of Cardiovascular Medicine, General Hospital of Ningxia Medical University, Institute of Cardiology, Ningxia Medical University, 804 Shengli St, Xinqing, Yinchuan, Ningxia, China.
Email: [email protected], [email protected] and [email protected]
Search for more papers by this authorCorresponding Author
Ru Yan MD
Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, China
Institute of Cardiovascular Medicine, General Hospital of Ningxia Medical University, Yinchuan, China
Department of Cardiology, General Hospital of Ningxia Medical University, Ningxia Medical University, Yinchuan, China
Correspondence Guangzhi Cong, PhD, Ru Yan, MD, and Shaobin Jia, PhD, Department of Cardiovascular Medicine, General Hospital of Ningxia Medical University, Institute of Cardiology, Ningxia Medical University, 804 Shengli St, Xinqing, Yinchuan, Ningxia, China.
Email: [email protected], [email protected] and [email protected]
Search for more papers by this authorCorresponding Author
Guangzhi Cong PhD
Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, China
Institute of Cardiovascular Medicine, General Hospital of Ningxia Medical University, Yinchuan, China
Department of Cardiology, General Hospital of Ningxia Medical University, Ningxia Medical University, Yinchuan, China
Correspondence Guangzhi Cong, PhD, Ru Yan, MD, and Shaobin Jia, PhD, Department of Cardiovascular Medicine, General Hospital of Ningxia Medical University, Institute of Cardiology, Ningxia Medical University, 804 Shengli St, Xinqing, Yinchuan, Ningxia, China.
Email: [email protected], [email protected] and [email protected]
Search for more papers by this authorAbstract
Background
Acute kidney injury (AKI) is a frequent and potentially life-threatening complication after percutaneous coronary intervention (PCI) in patients with ST-segment-elevation myocardial infarction (STEMI). However, the relationship between obesity and the risk of AKI in this specific patient population has not been previously examined.
Methods
We queried the National Inpatient Sample (2016–2019) using ICD-10 codes to obtain a sample of adults with STEMI undergoing PCI. All patients were further subcategorized into obese and nonobese cohorts. The primary outcome was the incidence of AKI. Multivariate regression analysis was performed to assess the impact of obesity on AKI. The consistency of this correlation between subgroups was investigated using subgroup analysis and interaction testing.
Results
A total of 62,599 (weighted national estimate of 529,016) patients were identified, of which 9.80% (n = 6137) had AKI. Obesity comprised 19.78% (n = 1214) of the AKI cohort. Obese patients were on average younger, male, white, and had more comorbidities. Additionally, there was a significant positive association between obesity and AKI incidence (adjusted odds ratio [aOR]: 1.24, 95% confidence interval [CI]: 1.15–1.34), which was more pronounced in female patients (aOR: 1.56, 95% CI: 1.33–1.82, p < 0.001, p-interaction = 0.008). The AKI incidence in these patients increased steadily during the 4-year study period, and it was consistently higher in obese patients than in nonobese patients (p-trend < 0.001 for all).
Conclusions
Obesity was independently associated with a greater risk of AKI among adults with STEMI undergoing PCI, particularly in female patients.
CONFLICT OF INTEREST STATEMENT
The authors declare no conflict of interest.
Open Research
DATA AVAILABILITY STATEMENT
The data that support the findings of this study are openly available in The National (Nationwide) Inpatient Sample (NIS) at https://hcup-us.ahrq.gov/nisoverview.jsp.
Supporting Information
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