Catheterization and Cardiovascular Interventions

Volume 98, Issue 5 pp. E758-E767

Original Studies

Prognostic implication of right ventricular dysfunction and tricuspid regurgitation following transcatheter aortic valve replacement

Yoav Granot MD,

Corresponding Author

Yoav Granot MD

[email protected]

orcid.org/0000-0002-3863-4493

Department of Cardiology, Tel Aviv Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

Correspondence

Yoav Granot, Department of Cardiology, Tel Aviv Medical Center, 6 Weizman Street, Tel Aviv, Israel.

Email: [email protected]

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Ilan Merdler MD,

Ilan Merdler MD

orcid.org/0000-0003-3294-5968

Department of Cardiology, Tel Aviv Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

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Ariel Finkelstein MD,

Ariel Finkelstein MD

Department of Cardiology, Tel Aviv Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

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Yaron Arbel MD,

Yaron Arbel MD

Department of Cardiology, Tel Aviv Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

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Shmuel Banai MD,

Shmuel Banai MD

Department of Cardiology, Tel Aviv Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

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Yan Topilsky MD,

Yan Topilsky MD

Department of Cardiology, Tel Aviv Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

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Lorin Arie Scwartz MD,

Lorin Arie Scwartz MD

Department of Cardiology, Tel Aviv Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

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Amit Segev MD,

Amit Segev MD

Leviev Heart Center, Chaim Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

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Israel Barbash MD,

Israel Barbash MD

orcid.org/0000-0002-7416-5989

Leviev Heart Center, Chaim Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

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Paul Fefer MD,

Paul Fefer MD

Leviev Heart Center, Chaim Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

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Haim Danenberg MD,

Haim Danenberg MD

Cardiology Department, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel

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Mony Shuvy MD,

Mony Shuvy MD

Cardiology Department, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel

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Gidon Perlman MD,

Gidon Perlman MD

Cardiology Department, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel

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Ran Kornowski MD,

Ran Kornowski MD

orcid.org/0000-0002-7708-8253

Cardiology Department, Rabin Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

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Yaron Shapira MD,

Yaron Shapira MD

Cardiology Department, Rabin Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

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Katia Orvin MD,

Katia Orvin MD

orcid.org/0000-0003-2523-6469

Cardiology Department, Rabin Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

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Arie Steinvil MD,

Arie Steinvil MD

orcid.org/0000-0002-6070-4187

Department of Cardiology, Tel Aviv Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

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Yoav Granot MD,

Corresponding Author

Yoav Granot MD

[email protected]

orcid.org/0000-0002-3863-4493

Department of Cardiology, Tel Aviv Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

Correspondence

Yoav Granot, Department of Cardiology, Tel Aviv Medical Center, 6 Weizman Street, Tel Aviv, Israel.

Email: [email protected]

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Ilan Merdler MD,

Ilan Merdler MD

orcid.org/0000-0003-3294-5968

Department of Cardiology, Tel Aviv Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

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Ariel Finkelstein MD,

Ariel Finkelstein MD

Department of Cardiology, Tel Aviv Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

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Yaron Arbel MD,

Yaron Arbel MD

Department of Cardiology, Tel Aviv Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

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Shmuel Banai MD,

Shmuel Banai MD

Department of Cardiology, Tel Aviv Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

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Yan Topilsky MD,

Yan Topilsky MD

Department of Cardiology, Tel Aviv Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

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Lorin Arie Scwartz MD,

Lorin Arie Scwartz MD

Department of Cardiology, Tel Aviv Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

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Amit Segev MD,

Amit Segev MD

Leviev Heart Center, Chaim Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

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Israel Barbash MD,

Israel Barbash MD

orcid.org/0000-0002-7416-5989

Leviev Heart Center, Chaim Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

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Paul Fefer MD,

Paul Fefer MD

Leviev Heart Center, Chaim Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

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Haim Danenberg MD,

Haim Danenberg MD

Cardiology Department, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel

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Mony Shuvy MD,

Mony Shuvy MD

Cardiology Department, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel

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Gidon Perlman MD,

Gidon Perlman MD

Cardiology Department, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel

Search for more papers by this author

Ran Kornowski MD,

Ran Kornowski MD

orcid.org/0000-0002-7708-8253

Cardiology Department, Rabin Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

Search for more papers by this author

Yaron Shapira MD,

Yaron Shapira MD

Cardiology Department, Rabin Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

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Katia Orvin MD,

Katia Orvin MD

orcid.org/0000-0003-2523-6469

Cardiology Department, Rabin Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

Search for more papers by this author

Arie Steinvil MD,

Arie Steinvil MD

orcid.org/0000-0002-6070-4187

Department of Cardiology, Tel Aviv Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

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First published: 07 March 2021

https://doi.org/10.1002/ccd.29639

Citations: 5

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Abstract

Objectives

Right ventricular (RV) dysfunction and tricuspid regurgitation (TR) are associated with adverse outcomes in severe aortic stenosis (AS) patients. Our aim was to evaluate the association between ≥moderate TR and RV dysfunction on long-term mortality following transcatheter aortic valve replacement (TAVR).

Methods

A retrospective analysis of the Israeli multicenter TAVR registry among 4,344 consecutive patients, with all-cause mortality as the main outcome measure.

Results

Echocardiographic assessment of TR grade and RV dysfunction was available for 3,733 and 1,850 patients, of whom ≥moderate TR and RV dysfunction was noted for 478(13%) and 78(4%), respectively. The mean follow-up time was 2.9 ± 2.3 years. In univariate models, ≥Moderate TR and ≥moderate RV dysfunction were associated with increased long-term mortality (HR 1.45, 95% CI 1.24–1.69, p < .001 and HR 1.73, 95% CI 1.21–2.47, p = 0.003, respectively). These finding did not remained significant after adjusting to echocardiographic parameters. A subset of patients with no improvement in RV function had the highest long-term mortality risk (HR 3.3, 95% CI 1.95–5.7, p < .001).

Conclusion

When adjusted to multiple echocardiographic characteristics baseline ≥Moderate TR and ≥moderate RV dysfunction were not associated with long-term mortality following TAVR. Persistent RV dysfunction following TAVR was associated with the highest risk for mortality.

CONFLICT OF INTEREST

The authors declare no potential conflict of interest.

Open Research

DATA AVAILABILITY STATEMENT

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Volume98, Issue5

November 1, 2021

Pages E758-E767

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Prognostic implication of right ventricular dysfunction and tricuspid regurgitation following transcatheter aortic valve replacement

Abstract

Objectives

Methods

Results

Conclusion

CONFLICT OF INTEREST

Open Research

DATA AVAILABILITY STATEMENT

REFERENCES

Citing Literature

References

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Prognostic implication of right ventricular dysfunction and tricuspid regurgitation following transcatheter aortic valve replacement

Abstract

Objectives

Methods

Results

Conclusion

CONFLICT OF INTEREST

Open Research

DATA AVAILABILITY STATEMENT

REFERENCES

Citing Literature

References

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