Volume 20, Issue 2 e202201111
Research Article

Five New Phenylpropanoyl Phloroglucinol Derivatives from Leptospermum scoparium

Ji-Hong Gu

Ji-Hong Gu

Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405 P. R. China

These authors contributed equally to this work.

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Jun-Shan Liu

Jun-Shan Liu

Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515 P. R. China

These authors contributed equally to this work.

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Jia-Hui Lin

Jia-Hui Lin

Center for Bioactive Natural Molecules and Innovative Drugs Research, and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632 P. R. China

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Fen Liu

Fen Liu

Center for Bioactive Natural Molecules and Innovative Drugs Research, and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632 P. R. China

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Zhen-Long Wu

Zhen-Long Wu

Center for Bioactive Natural Molecules and Innovative Drugs Research, and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632 P. R. China

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Yuan-Ru Zheng

Yuan-Ru Zheng

Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515 P. R. China

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Wen-Cai Ye

Corresponding Author

Wen-Cai Ye

Center for Bioactive Natural Molecules and Innovative Drugs Research, and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632 P. R. China

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Lei Wang

Corresponding Author

Lei Wang

Center for Bioactive Natural Molecules and Innovative Drugs Research, and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632 P. R. China

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First published: 22 December 2022
Citations: 1

Abstract

Leptosperols C−G (15), five new phenylpropanoyl phloroglucinol derivatives were isolated from the leaves of Leptospermum scoparium. Compounds 1–3 are phenylpropanoyl phloroglucinol-sesquiterpene adducts with new carbon skeletons. Their structures with absolute configurations were elucidated by detailed spectroscopic analyses, single-crystal X-ray diffraction, and electronic circular dichroism (ECD) calculation. Compounds 2 and 3 exhibited moderate anti-inflammatory activity in zebrafish acute inflammatory models.

Graphical Abstract

Conflict of interest

The authors declare no conflict of interest.

Data Availability Statement

The data that support the findings of this study are available in the supplementary material of this article.

The full text of this article hosted at iucr.org is unavailable due to technical difficulties.