Five New Phenylpropanoyl Phloroglucinol Derivatives from Leptospermum scoparium
Ji-Hong Gu
Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405 P. R. China
These authors contributed equally to this work.
Search for more papers by this authorJun-Shan Liu
Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515 P. R. China
These authors contributed equally to this work.
Search for more papers by this authorJia-Hui Lin
Center for Bioactive Natural Molecules and Innovative Drugs Research, and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632 P. R. China
Search for more papers by this authorFen Liu
Center for Bioactive Natural Molecules and Innovative Drugs Research, and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632 P. R. China
Search for more papers by this authorZhen-Long Wu
Center for Bioactive Natural Molecules and Innovative Drugs Research, and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632 P. R. China
Search for more papers by this authorYuan-Ru Zheng
Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515 P. R. China
Search for more papers by this authorCorresponding Author
Wen-Cai Ye
Center for Bioactive Natural Molecules and Innovative Drugs Research, and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632 P. R. China
Search for more papers by this authorCorresponding Author
Lei Wang
Center for Bioactive Natural Molecules and Innovative Drugs Research, and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632 P. R. China
Search for more papers by this authorJi-Hong Gu
Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405 P. R. China
These authors contributed equally to this work.
Search for more papers by this authorJun-Shan Liu
Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515 P. R. China
These authors contributed equally to this work.
Search for more papers by this authorJia-Hui Lin
Center for Bioactive Natural Molecules and Innovative Drugs Research, and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632 P. R. China
Search for more papers by this authorFen Liu
Center for Bioactive Natural Molecules and Innovative Drugs Research, and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632 P. R. China
Search for more papers by this authorZhen-Long Wu
Center for Bioactive Natural Molecules and Innovative Drugs Research, and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632 P. R. China
Search for more papers by this authorYuan-Ru Zheng
Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515 P. R. China
Search for more papers by this authorCorresponding Author
Wen-Cai Ye
Center for Bioactive Natural Molecules and Innovative Drugs Research, and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632 P. R. China
Search for more papers by this authorCorresponding Author
Lei Wang
Center for Bioactive Natural Molecules and Innovative Drugs Research, and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632 P. R. China
Search for more papers by this authorAbstract
Leptosperols C−G (1–5), five new phenylpropanoyl phloroglucinol derivatives were isolated from the leaves of Leptospermum scoparium. Compounds 1–3 are phenylpropanoyl phloroglucinol-sesquiterpene adducts with new carbon skeletons. Their structures with absolute configurations were elucidated by detailed spectroscopic analyses, single-crystal X-ray diffraction, and electronic circular dichroism (ECD) calculation. Compounds 2 and 3 exhibited moderate anti-inflammatory activity in zebrafish acute inflammatory models.
Graphical Abstract
Conflict of interest
The authors declare no conflict of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available in the supplementary material of this article.
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