Cytotoxic Sesquiterpenoids from Atractylodes chinensis (DC.) Koidz.
Lei-Xin Zhuang
Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, 150040 P. R. China
Search for more papers by this authorYan Liu
Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, 150040 P. R. China
Search for more papers by this authorSi-Yi Wang
Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, 150040 P. R. China
Search for more papers by this authorYe Sun
Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, 150040 P. R. China
Search for more papers by this authorJuan Pan
Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, 150040 P. R. China
Search for more papers by this authorWei Guan
Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, 150040 P. R. China
Search for more papers by this authorZhi-Chao Hao
Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, 150040 P. R. China
Search for more papers by this authorCorresponding Author
Hai-Xue Kuang
Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, 150040 P. R. China
Search for more papers by this authorCorresponding Author
Bing-You Yang
Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, 150040 P. R. China
Search for more papers by this authorLei-Xin Zhuang
Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, 150040 P. R. China
Search for more papers by this authorYan Liu
Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, 150040 P. R. China
Search for more papers by this authorSi-Yi Wang
Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, 150040 P. R. China
Search for more papers by this authorYe Sun
Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, 150040 P. R. China
Search for more papers by this authorJuan Pan
Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, 150040 P. R. China
Search for more papers by this authorWei Guan
Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, 150040 P. R. China
Search for more papers by this authorZhi-Chao Hao
Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, 150040 P. R. China
Search for more papers by this authorCorresponding Author
Hai-Xue Kuang
Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, 150040 P. R. China
Search for more papers by this authorCorresponding Author
Bing-You Yang
Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, 150040 P. R. China
Search for more papers by this authorAbstract
Four new sesquiterpenoids named atrchiterpenes A–D (1–4), a new natural product (5), and twelve known compounds (6–17) were isolated from Atractylodes chinensis (DC.) Koidz. Compound 1 was a rare N-containing eudesmane-type sesquiterpenoid. Structure elucidation was performed by spectroscopic techniques, including 1D, 2D NMR spectra, and HR-ESI-MS. Compounds 6–11, 14, and 17 were reported from Atractylodes for the first time. All the isolated compounds were evaluated for cytotoxicity activity. Compound 16 showed moderate cytotoxicity against HepG2 cells with an IC50 value of 5.81±0.47.
Graphical Abstract
Conflict of interest
The authors declare no conflict of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.
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