New Jatrophane-Type Diterpenoids from Euphorbia kansui as Potential MDR Reversal Agents
Qiong Zheng
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014 P. R. China
Search for more papers by this authorNing-Yu Chen
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014 P. R. China
Search for more papers by this authorSi-Qing Lou
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014 P. R. China
Search for more papers by this authorQian-Qing Liu
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014 P. R. China
Search for more papers by this authorYi-Tong Luo
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014 P. R. China
Search for more papers by this authorDong-E Liang
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014 P. R. China
Search for more papers by this authorZha-Jun Zhan
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014 P. R. China
Search for more papers by this authorCorresponding Author
Lie-Feng Ma
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014 P. R. China
Search for more papers by this authorQiong Zheng
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014 P. R. China
Search for more papers by this authorNing-Yu Chen
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014 P. R. China
Search for more papers by this authorSi-Qing Lou
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014 P. R. China
Search for more papers by this authorQian-Qing Liu
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014 P. R. China
Search for more papers by this authorYi-Tong Luo
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014 P. R. China
Search for more papers by this authorDong-E Liang
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014 P. R. China
Search for more papers by this authorZha-Jun Zhan
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014 P. R. China
Search for more papers by this authorCorresponding Author
Lie-Feng Ma
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014 P. R. China
Search for more papers by this authorAbstract
A serial jatrophane-type diterpenoids, comprised with three undescribed compounds kanesulones C−E (1–3) and four known ones (4–7), were obtained from the roots of Euphorbia kansui. The structures of compounds 1–3 were elucidated by detailed interpretation of their spectroscopic data, especially 2D-NMR and HR-ESI-MS, the absolute configuration of 1 was revealed by single crystal X-ray diffraction. These isolates were assayed for their multidrug resistance reversing activities on human breast adenocarcinoma cell line MCF-7/ADR. Compound 1 possessed potential as low toxic MDR modulator that could promote the efficacy of anticancer drug adriamycin ca. 85-fold at 5 μM, as 12 times stronger than the positive drug verapamil.
Graphical Abstract
Conflict of interest
The authors declare no conflict of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available in the supplementary material of this article.
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