New Avermectin Analogues from a Mutant Streptomyces avermectinius Strain
Youjun Zhang
Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai, 200433 P. R. China
Department of Naval Health Service and Medical Equipment, Faculty of Medicine, Second Military Medical University, 800 Xiang-Yin Road, Shanghai, 200433 P. R. China
Search for more papers by this authorCheng Zhang
Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai, 200433 P. R. China
Search for more papers by this authorKeke Wang
Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai, 200433 P. R. China
Search for more papers by this authorGuoliang Chen
Department of Naval Health Service and Medical Equipment, Faculty of Medicine, Second Military Medical University, 800 Xiang-Yin Road, Shanghai, 200433 P. R. China
Search for more papers by this authorPeng Sun
Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai, 200433 P. R. China
Search for more papers by this authorYoujun Zhang
Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai, 200433 P. R. China
Department of Naval Health Service and Medical Equipment, Faculty of Medicine, Second Military Medical University, 800 Xiang-Yin Road, Shanghai, 200433 P. R. China
Search for more papers by this authorCheng Zhang
Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai, 200433 P. R. China
Search for more papers by this authorKeke Wang
Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai, 200433 P. R. China
Search for more papers by this authorGuoliang Chen
Department of Naval Health Service and Medical Equipment, Faculty of Medicine, Second Military Medical University, 800 Xiang-Yin Road, Shanghai, 200433 P. R. China
Search for more papers by this authorPeng Sun
Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai, 200433 P. R. China
Search for more papers by this authorAbstract
Two new avemectin analogues 1 and 2 belonging to ‘b’ series of components were isolated from a ∆aveCDE mutant Streptomyces avermectinius strain. Their structures were elucidated by detailed analysis of NMR and MS spectroscopic data. Compounds 1 and 2 displayed moderate cytotoxicities against B16, MG-63, and Saos-2 cell lines in an in vitro assay.
Graphical Abstract
Supporting Information
Supporting information for this article is available on the WWW under https://doi.org/10.1002/cbdv.201700054
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