Polyketides from Mantis-Associated Fungus Daldinia eschscholzii IFB-TL01
Gang Wang
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China (phone/fax: +86-25-83593201)
These authors contributed equally to this work.
Search for more papers by this authorJing-Yang Fan
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China (phone/fax: +86-25-83593201)
These authors contributed equally to this work.
Search for more papers by this authorWen-Jing Zhang
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China (phone/fax: +86-25-83593201)
Search for more papers by this authorCheng-Pin Hua
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China (phone/fax: +86-25-83593201)
Search for more papers by this authorChao-Jun Chen
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China (phone/fax: +86-25-83593201)
Search for more papers by this authorWei Yan
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China (phone/fax: +86-25-83593201)
Search for more papers by this authorHui-Ming Ge
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China (phone/fax: +86-25-83593201)
Search for more papers by this authorCorresponding Author
Rui-Hua Jiao
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China (phone/fax: +86-25-83593201)
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China (phone/fax: +86-25-83593201)Search for more papers by this authorRen-Xiang Tan
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China (phone/fax: +86-25-83593201)
Search for more papers by this authorGang Wang
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China (phone/fax: +86-25-83593201)
These authors contributed equally to this work.
Search for more papers by this authorJing-Yang Fan
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China (phone/fax: +86-25-83593201)
These authors contributed equally to this work.
Search for more papers by this authorWen-Jing Zhang
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China (phone/fax: +86-25-83593201)
Search for more papers by this authorCheng-Pin Hua
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China (phone/fax: +86-25-83593201)
Search for more papers by this authorChao-Jun Chen
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China (phone/fax: +86-25-83593201)
Search for more papers by this authorWei Yan
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China (phone/fax: +86-25-83593201)
Search for more papers by this authorHui-Ming Ge
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China (phone/fax: +86-25-83593201)
Search for more papers by this authorCorresponding Author
Rui-Hua Jiao
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China (phone/fax: +86-25-83593201)
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China (phone/fax: +86-25-83593201)Search for more papers by this authorRen-Xiang Tan
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China (phone/fax: +86-25-83593201)
Search for more papers by this authorAbstract
Three new polyketides, named daldinone F (1), nodulisporin G (2), and dalmanol C (3), together with five known compounds, 4–8, were isolated from cultures of Daldinia eschscholzii. The structures of the new compounds were elucidated by extensive NMR and MS analyses. Compound 1 showed moderate cytotoxic activity against SW480 cancer cells with an IC50 value of 9.59 μM, and its absolute configuration was determined by single crystal X-ray diffraction.
Graphical Abstract
References
- 1 X.-B. Li, F. Xie, S.-S. Liu, Y. Li, J.-C. Zhou, Y.-Q. Liu, H.-Q. Yuan, H.-X. Lou, Chem. Biodiversity 2013, 10, 1193.
- 2 S. Cao, L. Ross, G. Tamayo, J. Clardy, Org. Lett. 2010, 12, 4661.
- 3 Y. L. Zhang, H. M. Ge, W. Zhao, H. Dong, Q. Xu, S. H. Li, J. Li, J. Zhang, Y. C. Song, R. X. Tan, Angew. Chem., Int. Ed. 2008, 47, 5823.
- 4 Y. L. Zhang, J. Zhang, N. Jiang, Y. H. Lu, L. Wang, S. H. Xu, W. Wang, G. F. Zhang, Q. Xu, H. M. Ge, J. Ma, Y. C. Song, R. X. Tan, J. Am. Chem. Soc. 2011, 133, 5931.
- 5 W. Fang, S. Ji, N. Jiang, W. Wang, G. Y. Zhao, S. Zhang, H. M. Ge, Q. Xu, A. H. Zhang, Y. L. Zhang, Y. C. Song, J. Zhang, R. X. Tan, Nat. Commun. 2012, 3, 1039.
- 6 W. Gu, H. M. Ge, Y. C. Song, H. Ding, H. L. Zhu, X. A. Zhao, R. X. Tan, J. Nat. Prod. 2007, 70, 114.
- 7 J. Dai, K. Krohn, S. Draeger, B. Schulz, Eur. J. Org. Chem. 2009, 1564.
- 8 P. Venkatasubbaiah, W. S. Chilton, J. Nat. Prod. 1991, 54, 1293.
- 9 J. R. Anderson, R. L. Edwards, A. J. S. Whalley, J. Chem. Soc., Perkin Trans. 1 1983, 2185.
- 10 J. Dai, K. Krohn, U. Flörke, S. Draeger, B. Schulz, A. Kiss-Szikszai, S. Antus, T. Kurtán, T. van Ree, Eur. J. Org. Chem. 2006, 3498.
- 11 T. Mosmann, J. Immunol. Methods 1983, 65, 55.
