Research Article

Preparation of Guanine and Diaminopurine from Biuret. Part III^†

Irene M. Lagoja

[email protected]

Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, (phone: +32-16-337397; fax +32-16-337340)

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Piet Herdewijn,

Piet Herdewijn

Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, (phone: +32-16-337397; fax +32-16-337340)

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Irene M. Lagoja,

Irene M. Lagoja

[email protected]

Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, (phone: +32-16-337397; fax +32-16-337340)

Search for more papers by this author

Piet Herdewijn,

Piet Herdewijn

Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, (phone: +32-16-337397; fax +32-16-337340)

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First published: 19 April 2007

https://doi.org/10.1002/cbdv.200790066

Citations: 3

^†

For Part I, see [1]; for Part II, see [2].

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Abstract

Because of their potential prebiotic origin and relative chemical stability, urea, biuret, formic acid, and glycine amide might have played a role in the assembly process of purine bases. In this paper, we describe a short reaction path to purine nucleobases from these acyclic precursors. The formation of different purines was verified by UV and NMR spectroscopy, as well as by mass spectrometry.

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Volume4, Issue4

April 2007

Pages 818-822

Preparation of Guanine and Diaminopurine from Biuret. Part III^†

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Preparation of Guanine and Diaminopurine from Biuret. Part III†

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Preparation of Guanine and Diaminopurine from Biuret. Part III^†