Research Article

Chemical Etiology of Nucleic Acids: Aminopropyl Nucleic Acids (APNAs)

Ding Zhou

Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, (phone: +32-16-337387; fax: +32-16-337340)

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Matheus Froeyen,

Matheus Froeyen

Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, (phone: +32-16-337387; fax: +32-16-337340)

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Jozef Rozenski,

Jozef Rozenski

Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, (phone: +32-16-337387; fax: +32-16-337340)

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Arthur Van Aerschot,

Arthur Van Aerschot

Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, (phone: +32-16-337387; fax: +32-16-337340)

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Piet Herdewijn,

Piet Herdewijn

[email protected]

Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, (phone: +32-16-337387; fax: +32-16-337340)

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Ding Zhou,

Ding Zhou

Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, (phone: +32-16-337387; fax: +32-16-337340)

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Matheus Froeyen,

Matheus Froeyen

Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, (phone: +32-16-337387; fax: +32-16-337340)

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Jozef Rozenski,

Jozef Rozenski

Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, (phone: +32-16-337387; fax: +32-16-337340)

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Arthur Van Aerschot,

Arthur Van Aerschot

Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, (phone: +32-16-337387; fax: +32-16-337340)

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Piet Herdewijn,

Piet Herdewijn

[email protected]

Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, (phone: +32-16-337387; fax: +32-16-337340)

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First published: 19 April 2007

https://doi.org/10.1002/cbdv.200790061

Citations: 3

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Abstract

Aminopropyl nucleic acids (APNAs) are constitutionally simple nucleic acid alternatives with one stereogenic center per nucleotide, and with the potential to hybridize with RNA and to exert catalytic functions. We have developed a protecting group strategy to synthesize APNAs, although in a not very efficient way. Isolation and purification of APNAs proved to be difficult. Their structures might be more suited to function as potential catalytic polymers than as information systems that may evolve into RNA.

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Volume4, Issue4

April 2007

Pages 740-761

Chemical Etiology of Nucleic Acids: Aminopropyl Nucleic Acids (APNAs)

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Chemical Etiology of Nucleic Acids: Aminopropyl Nucleic Acids (APNAs)

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