Volume 3, Issue 12 pp. 1301-1306
Research Article

A Study on Medicinal Plants from Malaysia Focused on Acalypha siamensis Oliv. ex Gage. Isolation and Structure of a New Tetraterpene, Acalyphaser A

Hiroto Kambara

Hiroto Kambara

Faculty of Pharmaceutical Science, Life Science Center and Center for Area Research and Development (CARD), Kobe Gakuin University, 518 Arise Ikawadani-cho, Nishi-ku, Kobe 651-2180, Japan (phone: +81-78-974-4765; fax: +81-78-974-5689)

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Takeshi Yamada

Takeshi Yamada

Osaka University of Pharmaceutical Sciences, 4-20-1, Dr. T. Yamada, Nasahara, Takatsuki, Osaka 569-1094, Japan (phone: +81-0726-90-1084)

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Makiko Tsujioka

Makiko Tsujioka

Osaka University of Pharmaceutical Sciences, 4-20-1, Dr. T. Yamada, Nasahara, Takatsuki, Osaka 569-1094, Japan (phone: +81-0726-90-1084)

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Shunyo Matsunaga

Shunyo Matsunaga

Osaka University of Pharmaceutical Sciences, 4-20-1, Dr. T. Yamada, Nasahara, Takatsuki, Osaka 569-1094, Japan (phone: +81-0726-90-1084)

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Reiko Tanaka

Reiko Tanaka

Osaka University of Pharmaceutical Sciences, 4-20-1, Dr. T. Yamada, Nasahara, Takatsuki, Osaka 569-1094, Japan (phone: +81-0726-90-1084)

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Hamed I. Ali

Hamed I. Ali

Department of Molecular Pharmaceutical Chemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 1-1-1, Tsushima-Naka, Okayama 700-8530, Japan

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Christophe Wiart

Christophe Wiart

Department of Pharmacy, Faculty of Medicine, University of Malaya, Malaysia

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Mohd Yusof

Mohd Yusof

Department of Medicinal Microbiology, Faculty of Medicine, University of Malaya, Malaysia

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Hamina Hassan

Hamina Hassan

Department of Medicinal Microbiology, Faculty of Medicine, University of Malaya, Malaysia

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Abu Hanifah

Abu Hanifah

Department of Medicinal Microbiology, Faculty of Medicine, University of Malaya, Malaysia

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Zeesharina Mohd Fauzi

Zeesharina Mohd Fauzi

Department of Medicinal Microbiology, Faculty of Medicine, University of Malaya, Malaysia

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Nor Hana Mazlan

Nor Hana Mazlan

Department of Medicinal Microbiology, Faculty of Medicine, University of Malaya, Malaysia

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Michael Jay

Michael Jay

Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY 40536-0082, USA

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Munetaka Kunishima

Munetaka Kunishima

Faculty of Pharmaceutical Science, Life Science Center and Center for Area Research and Development (CARD), Kobe Gakuin University, 518 Arise Ikawadani-cho, Nishi-ku, Kobe 651-2180, Japan (phone: +81-78-974-4765; fax: +81-78-974-5689)

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Eiichi Akaho

Eiichi Akaho

Faculty of Pharmaceutical Science, Life Science Center and Center for Area Research and Development (CARD), Kobe Gakuin University, 518 Arise Ikawadani-cho, Nishi-ku, Kobe 651-2180, Japan (phone: +81-78-974-4765; fax: +81-78-974-5689)

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First published: 18 December 2006
Citations: 10

Abstract

As a part of our chemical studies on Malaysian medicinal plants, five Malaysian plant species were evaluated by cytotoxicity assays using P388 murine leukemia cells. Since Acalypha siamensis exhibited the strongest growth inhibition, its constituents were studied as the object of search for bioactive materials. A novel tetraterpene, acalyphaser A (1), was isolated in the course of the purification. Its structure was elucidated on the basis of 1D- and 2D-NMR techniques, and mass spectrometry.

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