A Study on Medicinal Plants from Malaysia Focused on Acalypha siamensis Oliv. ex Gage. Isolation and Structure of a New Tetraterpene, Acalyphaser A
Hiroto Kambara
Faculty of Pharmaceutical Science, Life Science Center and Center for Area Research and Development (CARD), Kobe Gakuin University, 518 Arise Ikawadani-cho, Nishi-ku, Kobe 651-2180, Japan (phone: +81-78-974-4765; fax: +81-78-974-5689)
Search for more papers by this authorTakeshi Yamada
Osaka University of Pharmaceutical Sciences, 4-20-1, Dr. T. Yamada, Nasahara, Takatsuki, Osaka 569-1094, Japan (phone: +81-0726-90-1084)
Search for more papers by this authorMakiko Tsujioka
Osaka University of Pharmaceutical Sciences, 4-20-1, Dr. T. Yamada, Nasahara, Takatsuki, Osaka 569-1094, Japan (phone: +81-0726-90-1084)
Search for more papers by this authorShunyo Matsunaga
Osaka University of Pharmaceutical Sciences, 4-20-1, Dr. T. Yamada, Nasahara, Takatsuki, Osaka 569-1094, Japan (phone: +81-0726-90-1084)
Search for more papers by this authorReiko Tanaka
Osaka University of Pharmaceutical Sciences, 4-20-1, Dr. T. Yamada, Nasahara, Takatsuki, Osaka 569-1094, Japan (phone: +81-0726-90-1084)
Search for more papers by this authorHamed I. Ali
Department of Molecular Pharmaceutical Chemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 1-1-1, Tsushima-Naka, Okayama 700-8530, Japan
Search for more papers by this authorChristophe Wiart
Department of Pharmacy, Faculty of Medicine, University of Malaya, Malaysia
Search for more papers by this authorMohd Yusof
Department of Medicinal Microbiology, Faculty of Medicine, University of Malaya, Malaysia
Search for more papers by this authorHamina Hassan
Department of Medicinal Microbiology, Faculty of Medicine, University of Malaya, Malaysia
Search for more papers by this authorAbu Hanifah
Department of Medicinal Microbiology, Faculty of Medicine, University of Malaya, Malaysia
Search for more papers by this authorZeesharina Mohd Fauzi
Department of Medicinal Microbiology, Faculty of Medicine, University of Malaya, Malaysia
Search for more papers by this authorNor Hana Mazlan
Department of Medicinal Microbiology, Faculty of Medicine, University of Malaya, Malaysia
Search for more papers by this authorMichael Jay
Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY 40536-0082, USA
Search for more papers by this authorMunetaka Kunishima
Faculty of Pharmaceutical Science, Life Science Center and Center for Area Research and Development (CARD), Kobe Gakuin University, 518 Arise Ikawadani-cho, Nishi-ku, Kobe 651-2180, Japan (phone: +81-78-974-4765; fax: +81-78-974-5689)
Search for more papers by this authorEiichi Akaho
Faculty of Pharmaceutical Science, Life Science Center and Center for Area Research and Development (CARD), Kobe Gakuin University, 518 Arise Ikawadani-cho, Nishi-ku, Kobe 651-2180, Japan (phone: +81-78-974-4765; fax: +81-78-974-5689)
Search for more papers by this authorHiroto Kambara
Faculty of Pharmaceutical Science, Life Science Center and Center for Area Research and Development (CARD), Kobe Gakuin University, 518 Arise Ikawadani-cho, Nishi-ku, Kobe 651-2180, Japan (phone: +81-78-974-4765; fax: +81-78-974-5689)
Search for more papers by this authorTakeshi Yamada
Osaka University of Pharmaceutical Sciences, 4-20-1, Dr. T. Yamada, Nasahara, Takatsuki, Osaka 569-1094, Japan (phone: +81-0726-90-1084)
Search for more papers by this authorMakiko Tsujioka
Osaka University of Pharmaceutical Sciences, 4-20-1, Dr. T. Yamada, Nasahara, Takatsuki, Osaka 569-1094, Japan (phone: +81-0726-90-1084)
Search for more papers by this authorShunyo Matsunaga
Osaka University of Pharmaceutical Sciences, 4-20-1, Dr. T. Yamada, Nasahara, Takatsuki, Osaka 569-1094, Japan (phone: +81-0726-90-1084)
Search for more papers by this authorReiko Tanaka
Osaka University of Pharmaceutical Sciences, 4-20-1, Dr. T. Yamada, Nasahara, Takatsuki, Osaka 569-1094, Japan (phone: +81-0726-90-1084)
Search for more papers by this authorHamed I. Ali
Department of Molecular Pharmaceutical Chemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 1-1-1, Tsushima-Naka, Okayama 700-8530, Japan
Search for more papers by this authorChristophe Wiart
Department of Pharmacy, Faculty of Medicine, University of Malaya, Malaysia
Search for more papers by this authorMohd Yusof
Department of Medicinal Microbiology, Faculty of Medicine, University of Malaya, Malaysia
Search for more papers by this authorHamina Hassan
Department of Medicinal Microbiology, Faculty of Medicine, University of Malaya, Malaysia
Search for more papers by this authorAbu Hanifah
Department of Medicinal Microbiology, Faculty of Medicine, University of Malaya, Malaysia
Search for more papers by this authorZeesharina Mohd Fauzi
Department of Medicinal Microbiology, Faculty of Medicine, University of Malaya, Malaysia
Search for more papers by this authorNor Hana Mazlan
Department of Medicinal Microbiology, Faculty of Medicine, University of Malaya, Malaysia
Search for more papers by this authorMichael Jay
Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY 40536-0082, USA
Search for more papers by this authorMunetaka Kunishima
Faculty of Pharmaceutical Science, Life Science Center and Center for Area Research and Development (CARD), Kobe Gakuin University, 518 Arise Ikawadani-cho, Nishi-ku, Kobe 651-2180, Japan (phone: +81-78-974-4765; fax: +81-78-974-5689)
Search for more papers by this authorEiichi Akaho
Faculty of Pharmaceutical Science, Life Science Center and Center for Area Research and Development (CARD), Kobe Gakuin University, 518 Arise Ikawadani-cho, Nishi-ku, Kobe 651-2180, Japan (phone: +81-78-974-4765; fax: +81-78-974-5689)
Search for more papers by this authorAbstract
As a part of our chemical studies on Malaysian medicinal plants, five Malaysian plant species were evaluated by cytotoxicity assays using P388 murine leukemia cells. Since Acalypha siamensis exhibited the strongest growth inhibition, its constituents were studied as the object of search for bioactive materials. A novel tetraterpene, acalyphaser A (1), was isolated in the course of the purification. Its structure was elucidated on the basis of 1D- and 2D-NMR techniques, and mass spectrometry.
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