Correction to: ZNF582 hypermethylation promotes metastasis of nasopharyngeal carcinoma by regulating the transcription of adhesion molecules Nectin-3 and NRXN3
Following publication of this article [1], the authors noticed that the mismatched images were inadvertently included in Figure 5 (migration assays of SUNE1-shNRXN3-#2 group in Figure 5I) and Figure 6 (invasion assays of SUNE1-ZNF582+Nectin3 group in Figure 6A). This error has now been corrected online.
Both Nectin-3 and NRXN3 are functional targets of ZNF582 in NPC. (A) The mRNA expression level of Nectin-3 in NPC and normal nasopharyngeal tissue samples in the GSE12452 microarray dataset. (B) Correlation between Nectin-3 mRNA expression and ZNF582 expression in the GSE12452 dataset. (C) Western blotting of Nectin-3 in SUEN1 cells transfected with plasmids encoding empty vector, FLAG-Nectin-3, or Nectin-3-shRNAs. (D-E) Cell adhesion, migration, and invasion assays were performed in SUNE1 and HONE1 cells transfected with plasmids encoding control vector or Nectin-3 (D) or transfected with plasmids encoding shControl or Nectin-3-shRNA (E). (F) The mRNA expression level of NRNX3 in the GSE12452 microarray dataset. (G) Correlations between NRNX3 mRNA expression and ZNF582 expression in the GSE12452 dataset. (H) Western blotting of NRXN3 in SUEN1 cells transfected with plasmids encoding shControl or NRXN3-shRNAs. (I) Cell adhesion, migration, and invasion assays were performed in SUNE1 and HONE1 cells transfected with plasmids encoding shControl or NRNX3-shRNA (#1 or #2). Scale bar: 100 μm. All data are presented as mean ± standard deviation of at least three independent experiments. Student's t-test, **P < 0.01; ***P < 0.001. Abbreviations: NPC, nasopharyngeal carcinoma; shControl, control shRNA; shRNA, short-hairpin RNA.
ZNF582 inhibits NPC cell adhesion, migration, and invasion via Nectin-3 and NRXN3. (A-B) The cell adhesion, migration, and invasion assays were performed in SUNE1 and HONE1 cells stably overexpressed vector or ZNF582 and co-transfected with plasmids encoding empty vector or Nectin-3. (C-D) The cell adhesion, migration, and invasion assays were performed in SUNE1 and HONE1 cells stably overexpressed vector or ZNF582 and co-transfected with plasmids encoding empty vector or NRNX3-shRNA (#1 and #2). Scale bar: 100 μm. All data are presented as mean ± standard deviation of at least three independent experiments. Student's t-test, *P < 0.05, **P < 0.01, ***P < 0.001. Abbreviations: NPC, nasopharyngeal carcinoma; shControl, control shRNA; shRNA, short-hairpin RNA.
The original data has been submitted to the editorial board of Cancer Communications and has been approved. The authors apologize for this oversight. The correction has no effect on the validity and integrity of the work. We thank the first author, Dr. Yin Zhao, for noticing this mistake.
Author information
Yin Zhao1,†, Xiao-Hong Hong1,†, Kang Li2,†, Ying-Qing Li1,†, Ying-Qin Li1, Shi-Wei He1, Pan-Pan Zhang1, Jun-Yan Li1, Qian Li1, Ye-Lin Liang1, Yang Chen1, Jun Ma1, Na Liu1, Yu-Pei Chen1
Affiliations
1Experimental Research Department, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center of Cancer Medicine; Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou 510060, Guangdong, P. R. China
2Center for Translational Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong, P. R. China
†These authors contributed equally to this article
Yin Zhao, Xiao-Hong Hong, Kang Li, and Ying-Qing Li contributed equally to this work.
1Zhao Y, Hong XH, Li K, Li YQ, Li YQ, He SW, et al. ZNF582 hypermethylation promotes metastasis of nasopharyngeal carcinoma by regulating the transcription of adhesion molecules Nectin-3 and NRXN3. Cancer Communications (London, England), 2020, 40(12): 721-737. https://doi.org/10.1002/cac2.12104.
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