The conformation and ion-binding characteristics of a cyclic octapeptide, cyclo(Ala-Leu-Pro-Gly)₂, in a liphophilic solvent, acetonitrile, have been studied using CD and nmr spectroscopy. The peptide binds preferentially to divalent cations such as calcium, magnesium, and barium. The conformations of the free cyclic peptide and its calcium complex are very similar with well-defined β- and γ-turns. The cyclic peptide readily forms equimolar and possibly 2 : 1 (peptide:cation) complexes with divalent cations.

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Volume32, Issue8

August 1992

Pages 993-1001

Conformational and ion binding properties of a cyclic octapeptide, cyclo(Ala-Leu-Pro-Gly)₂

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Conformational and ion binding properties of a cyclic octapeptide, cyclo(Ala-Leu-Pro-Gly)2

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Conformational and ion binding properties of a cyclic octapeptide, cyclo(Ala-Leu-Pro-Gly)₂