Volume 10, Issue 5 pp. 443-451
Research Article
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Mean residence time: Some further consideration

Paul S. Collier

Paul S. Collier

Department of Pharmacy, The Queen's University of Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL Northern Ireland, U.K.

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First published: September/October 1989
Citations: 3

Abstract

The correct use of probability distribution functions is described for the determination of mean residence time (MRT) of drug molecules in the body and is illustrated for two possible two compartment body models. A new method for estimating (MRT) is described, based on the area under the curve measurement for the decay of drug from steady state.

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