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A promoter polymorphism of tumor necrosis factor α associated with systemic lupus erythematosus in African-Americans
Kathleen E. Sullivan MD, PhD,
Candra Wooten,
Barbara J. Schmeckpeper PhD,
Daniel Goldman PhD,
Michelle A. Petri MD, MPH,
Corresponding Author
Kathleen E. Sullivan MD, PhD
The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia
Division of Immunologic and Infectious Diseases, The Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104Search for more papers by this authorCandra Wooten
The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia
Search for more papers by this authorBarbara J. Schmeckpeper PhD
The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia
Search for more papers by this authorDaniel Goldman PhD
The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia
Search for more papers by this authorMichelle A. Petri MD, MPH
The Johns Hopkins University School of Medicine, Baltimore, Maryland
Search for more papers by this authorKathleen E. Sullivan MD, PhD,
Candra Wooten,
Barbara J. Schmeckpeper PhD,
Daniel Goldman PhD,
Michelle A. Petri MD, MPH,
Corresponding Author
Kathleen E. Sullivan MD, PhD
The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia
Division of Immunologic and Infectious Diseases, The Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104Search for more papers by this authorCandra Wooten
The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia
Search for more papers by this authorBarbara J. Schmeckpeper PhD
The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia
Search for more papers by this authorDaniel Goldman PhD
The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia
Search for more papers by this authorMichelle A. Petri MD, MPH
The Johns Hopkins University School of Medicine, Baltimore, Maryland
Search for more papers by this authorAbstract
Objective. The polymorphic tumor necrosis factor α (TNFα) gene encodes a cytokine involved in inflammation, angiogenesis, and apoptosis. One polymorphic variant is associated with increased production of TNFα. This study examined the frequency of this polymorphic variant in African-American patients with systemic lupus erythematosus (SLE) compared with controls.
Methods. We determined the gene frequency of the polymorphic variant of TNFα in an African- American SLE patient population and in a geographically matched African-American control population.
Results. The gene frequency of the TNFα -308A polymorphism was higher in the African-American SLE population than in the control population. This relationship was independent of major histocompatibility complex DR alleles.
Conclusion. The TNFα -308A polymorphism is associated with an increased risk of SLE in African- Americans.
Reference
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