Dna autosensitivity in two japanese sisters
Corresponding Author
Susumu Sugai MD
Division of Hematology and Immunology and the Division of Nephrology, Department of Internal Medicine, and the Departments of Plastic Surgery and Ophthalmology, Kanazawa Medical University, Ishikawa, Japan.
Division of Hematology and Immunology, Department of Internal Medicine, Kanazawa Medical University, Uchinada-machi, Kahoku-gun, Ishikawa 920–02, JapanSearch for more papers by this authorYukio Yasuda MD
Division of Hematology and Immunology and the Division of Nephrology, Department of Internal Medicine, and the Departments of Plastic Surgery and Ophthalmology, Kanazawa Medical University, Ishikawa, Japan.
Search for more papers by this authorShiro Shimizu MD
Division of Hematology and Immunology and the Division of Nephrology, Department of Internal Medicine, and the Departments of Plastic Surgery and Ophthalmology, Kanazawa Medical University, Ishikawa, Japan.
Search for more papers by this authorMakoto Sawada MD
Division of Hematology and Immunology and the Division of Nephrology, Department of Internal Medicine, and the Departments of Plastic Surgery and Ophthalmology, Kanazawa Medical University, Ishikawa, Japan.
Search for more papers by this authorJunko Tachibana MD
Division of Hematology and Immunology and the Division of Nephrology, Department of Internal Medicine, and the Departments of Plastic Surgery and Ophthalmology, Kanazawa Medical University, Ishikawa, Japan.
Search for more papers by this authorSusumu Konda MD
Division of Hematology and Immunology and the Division of Nephrology, Department of Internal Medicine, and the Departments of Plastic Surgery and Ophthalmology, Kanazawa Medical University, Ishikawa, Japan.
Search for more papers by this authorHirohisa Kitada MD
Division of Hematology and Immunology and the Division of Nephrology, Department of Internal Medicine, and the Departments of Plastic Surgery and Ophthalmology, Kanazawa Medical University, Ishikawa, Japan.
Search for more papers by this authorHiroko Nakaizumi MD
Division of Hematology and Immunology and the Division of Nephrology, Department of Internal Medicine, and the Departments of Plastic Surgery and Ophthalmology, Kanazawa Medical University, Ishikawa, Japan.
Search for more papers by this authorSadao Tsukada MD
Division of Hematology and Immunology and the Division of Nephrology, Department of Internal Medicine, and the Departments of Plastic Surgery and Ophthalmology, Kanazawa Medical University, Ishikawa, Japan.
Search for more papers by this authorCorresponding Author
Susumu Sugai MD
Division of Hematology and Immunology and the Division of Nephrology, Department of Internal Medicine, and the Departments of Plastic Surgery and Ophthalmology, Kanazawa Medical University, Ishikawa, Japan.
Division of Hematology and Immunology, Department of Internal Medicine, Kanazawa Medical University, Uchinada-machi, Kahoku-gun, Ishikawa 920–02, JapanSearch for more papers by this authorYukio Yasuda MD
Division of Hematology and Immunology and the Division of Nephrology, Department of Internal Medicine, and the Departments of Plastic Surgery and Ophthalmology, Kanazawa Medical University, Ishikawa, Japan.
Search for more papers by this authorShiro Shimizu MD
Division of Hematology and Immunology and the Division of Nephrology, Department of Internal Medicine, and the Departments of Plastic Surgery and Ophthalmology, Kanazawa Medical University, Ishikawa, Japan.
Search for more papers by this authorMakoto Sawada MD
Division of Hematology and Immunology and the Division of Nephrology, Department of Internal Medicine, and the Departments of Plastic Surgery and Ophthalmology, Kanazawa Medical University, Ishikawa, Japan.
Search for more papers by this authorJunko Tachibana MD
Division of Hematology and Immunology and the Division of Nephrology, Department of Internal Medicine, and the Departments of Plastic Surgery and Ophthalmology, Kanazawa Medical University, Ishikawa, Japan.
Search for more papers by this authorSusumu Konda MD
Division of Hematology and Immunology and the Division of Nephrology, Department of Internal Medicine, and the Departments of Plastic Surgery and Ophthalmology, Kanazawa Medical University, Ishikawa, Japan.
Search for more papers by this authorHirohisa Kitada MD
Division of Hematology and Immunology and the Division of Nephrology, Department of Internal Medicine, and the Departments of Plastic Surgery and Ophthalmology, Kanazawa Medical University, Ishikawa, Japan.
Search for more papers by this authorHiroko Nakaizumi MD
Division of Hematology and Immunology and the Division of Nephrology, Department of Internal Medicine, and the Departments of Plastic Surgery and Ophthalmology, Kanazawa Medical University, Ishikawa, Japan.
Search for more papers by this authorSadao Tsukada MD
Division of Hematology and Immunology and the Division of Nephrology, Department of Internal Medicine, and the Departments of Plastic Surgery and Ophthalmology, Kanazawa Medical University, Ishikawa, Japan.
Search for more papers by this authorAbstract
Two cases of DNA autosensitivity in Japanese sisters are reported. Both patients developed painful ecchymoses and other bleeding disorders. Skin tests with autologous leukocyte lysates and calf thymus DNA produced intermediate-type reactions that were identical to spontaneous skin reactions. Pretreatment of DNA with either DNase or chloroquine sulfate inhibited these reactions. Our studies suggest that anti-DNA antibodies might contribute to the clinical symptoms of this disorder.
References
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