Subclinical renal dysfunction in rheumatoid arthritis
Corresponding Author
Maarten Boers Md, Phd
Department of Rheumatology
Departments of Rheumatology, Nephrology, and Diagnostic Radiology, University Hospital, Leiden, The Netherlands.
Department of Rheumatology, University Hospital, C2-Q, Post Box 9600, Leiden 2300 RC, The NetherlandsSearch for more papers by this authorBen A. C. Dijkmans Md, Phd
Department of Rheumatology
Departments of Rheumatology, Nephrology, and Diagnostic Radiology, University Hospital, Leiden, The Netherlands.
Search for more papers by this authorFerdinand C. Breedveld Md, Phd
Department of Rheumatology
Departments of Rheumatology, Nephrology, and Diagnostic Radiology, University Hospital, Leiden, The Netherlands.
Search for more papers by this authorJan A. J. Camps BSc
Department of Diagnostic Radiology
Departments of Rheumatology, Nephrology, and Diagnostic Radiology, University Hospital, Leiden, The Netherlands.
Search for more papers by this authorPeter C. Chang MD
Department of Nephrology
Departments of Rheumatology, Nephrology, and Diagnostic Radiology, University Hospital, Leiden, The Netherlands.
Search for more papers by this authorPeter Van Brummelen PhD
Department of Nephrology
Departments of Rheumatology, Nephrology, and Diagnostic Radiology, University Hospital, Leiden, The Netherlands.
Search for more papers by this authorErnest K. J. Pauwels Md, Phd
Department of Diagnostic Radiology
Departments of Rheumatology, Nephrology, and Diagnostic Radiology, University Hospital, Leiden, The Netherlands.
Search for more papers by this authorArnold Cats Md, Phd
Department of Rheumatology
Departments of Rheumatology, Nephrology, and Diagnostic Radiology, University Hospital, Leiden, The Netherlands.
Search for more papers by this authorCorresponding Author
Maarten Boers Md, Phd
Department of Rheumatology
Departments of Rheumatology, Nephrology, and Diagnostic Radiology, University Hospital, Leiden, The Netherlands.
Department of Rheumatology, University Hospital, C2-Q, Post Box 9600, Leiden 2300 RC, The NetherlandsSearch for more papers by this authorBen A. C. Dijkmans Md, Phd
Department of Rheumatology
Departments of Rheumatology, Nephrology, and Diagnostic Radiology, University Hospital, Leiden, The Netherlands.
Search for more papers by this authorFerdinand C. Breedveld Md, Phd
Department of Rheumatology
Departments of Rheumatology, Nephrology, and Diagnostic Radiology, University Hospital, Leiden, The Netherlands.
Search for more papers by this authorJan A. J. Camps BSc
Department of Diagnostic Radiology
Departments of Rheumatology, Nephrology, and Diagnostic Radiology, University Hospital, Leiden, The Netherlands.
Search for more papers by this authorPeter C. Chang MD
Department of Nephrology
Departments of Rheumatology, Nephrology, and Diagnostic Radiology, University Hospital, Leiden, The Netherlands.
Search for more papers by this authorPeter Van Brummelen PhD
Department of Nephrology
Departments of Rheumatology, Nephrology, and Diagnostic Radiology, University Hospital, Leiden, The Netherlands.
Search for more papers by this authorErnest K. J. Pauwels Md, Phd
Department of Diagnostic Radiology
Departments of Rheumatology, Nephrology, and Diagnostic Radiology, University Hospital, Leiden, The Netherlands.
Search for more papers by this authorArnold Cats Md, Phd
Department of Rheumatology
Departments of Rheumatology, Nephrology, and Diagnostic Radiology, University Hospital, Leiden, The Netherlands.
Search for more papers by this authorAbstract
We studied renal function in 35 patients with chronic, seropositive rheumatoid arthritis (RA), of whom 7 had vasculitis, 10 had hypergammaglobulinemia, and 18 had neither of these 2 conditions. Findings included a decreased glomerular filtration rate in 8 patients, (micro)proteinuria in 11, a defective urine concentration in 10, and increased urinary tubular enzyme levels in 15. These results indicate that subclinical renal dysfunction is common in patients with chronic, seropositive RA. In addition, vasculitis and hypergammaglobulinemia were not identified as risk factors for renal dysfunction in the RA patients studied.
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