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Dqβ polymorphism and genetic susceptibility to felty's syndrome

Corresponding Author

K. L. SO Alex MA, PhD, MRCP

Rheumatology Unit, Department of Medicine, Royal Postgraduate Medical School, London, and the United Kingdom Transplant Service, Bristol, United Kingdom.

Rheumatology Unit, Department of Medicine, Royal Postgraduate Medical School, Du Cane Road, London W12, UKSearch for more papers by this author

Catherine A. Warner BSc,

Catherine A. Warner BSc

Rheumatology Unit, Department of Medicine, Royal Postgraduate Medical School, London, and the United Kingdom Transplant Service, Bristol, United Kingdom.

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David Sansom MA, PhD, MRCP,

David Sansom MA, PhD, MRCP

Rheumatology Unit, Department of Medicine, Royal Postgraduate Medical School, London, and the United Kingdom Transplant Service, Bristol, United Kingdom.

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Mark J. Walport PhD,

Mark J. Walport PhD

Rheumatology Unit, Department of Medicine, Royal Postgraduate Medical School, London, and the United Kingdom Transplant Service, Bristol, United Kingdom.

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K. L. SO Alex MA, PhD, MRCP,

Corresponding Author

K. L. SO Alex MA, PhD, MRCP

Rheumatology Unit, Department of Medicine, Royal Postgraduate Medical School, London, and the United Kingdom Transplant Service, Bristol, United Kingdom.

Rheumatology Unit, Department of Medicine, Royal Postgraduate Medical School, Du Cane Road, London W12, UKSearch for more papers by this author

Catherine A. Warner BSc,

Catherine A. Warner BSc

Rheumatology Unit, Department of Medicine, Royal Postgraduate Medical School, London, and the United Kingdom Transplant Service, Bristol, United Kingdom.

Search for more papers by this author

David Sansom MA, PhD, MRCP,

David Sansom MA, PhD, MRCP

Rheumatology Unit, Department of Medicine, Royal Postgraduate Medical School, London, and the United Kingdom Transplant Service, Bristol, United Kingdom.

Search for more papers by this author

Mark J. Walport PhD,

Mark J. Walport PhD

Rheumatology Unit, Department of Medicine, Royal Postgraduate Medical School, London, and the United Kingdom Transplant Service, Bristol, United Kingdom.

Search for more papers by this author

First published: August 1988

https://doi.org/10.1002/art.1780310808

Citations: 21

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Abstract

We used an oligonucleotide probe specific for a polymorphic sequence in the HLA-DQβ gene to investigate the role of DQ polymorphism in genetic susceptibility to Felty's syndrome (FS) and rheumatoid arthritis (RA). The sequence of this gene was identified from a complementary DNA library derived from an RA patient's B lymphoblastoid cell line. With this probe, we studied the prevalence of the specific DQβ allele in DR4 positive FS patients, RA patients, and normal control subjects. Significantly more FS patients (17 of 25) showed hybridization with this oligonucleotide probe, compared with the number of DR4 positive non-FS RA patients (7 of 23) and normal controls (7 of 21). The findings indicate that genes linked to the DQ region are important in determining susceptibility to FS.

Reference

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Volume31, Issue8

August 1988

Pages 990-994

Dqβ polymorphism and genetic susceptibility to felty's syndrome

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Dqβ polymorphism and genetic susceptibility to felty's syndrome

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