Volume 330, Issue 6 pp. 169-172
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N1-Hetaryl Substituted Pyridine- and Pyrazinecarboxamidrazones with Antimycobacterial Activity

Donald Ranft

Donald Ranft

Institut für Pharmazeutische Chemie, W.-Langenbeck-Str. 4, D-06120 Halle Borstel

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Gudrun Lehwark-Yvetot

Gudrun Lehwark-Yvetot

Forschungszentrum Borstel, Zentrum für Medizin und Biowissenschaften, Parkallee 4a, D-23845 Borstel

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Klaus-Jürgen Schaper

Klaus-Jürgen Schaper

Institut für Pharmazeutische Chemie, W.-Langenbeck-Str. 4, D-06120 Halle Borstel

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Axel Büge

Axel Büge

Institut für Pharmazeutische Chemie, W.-Langenbeck-Str. 4, D-06120 Halle Borstel

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First published: 23 September 2006
Citations: 12

Dedicated to Prof. Dr. W. Wiegreb on the occasion of his 65th birthday.

Abstract

A series of amidrazones was prepared and characterized by 1H NMR and mass spectroscopy. The substances were tested against M. tuberculosis, M. avium, M. intracellulare, and M. lufu. Compounds 11–13 exhibit a satisfactory inhibition of mycobacteria.

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