Silk nanofibrous scaffolds assembled by natural polysaccharide konjac glucomannan
Jiahui Xiao
State Key Laboratory for Hubei New Textile Materials and Advanced Processing Technologies, School of Textile Science and Engineering, Wuhan Textile University, Wuhan, China
Contribution: Data curation (lead), Investigation (equal), Methodology (lead)
Search for more papers by this authorYueyang Ji
State Key Laboratory for Hubei New Textile Materials and Advanced Processing Technologies, School of Textile Science and Engineering, Wuhan Textile University, Wuhan, China
Contribution: Investigation (lead)
Search for more papers by this authorZixin Gao
State Key Laboratory for Hubei New Textile Materials and Advanced Processing Technologies, School of Textile Science and Engineering, Wuhan Textile University, Wuhan, China
Contribution: Conceptualization (lead)
Search for more papers by this authorYunfeng Dai
State Key Laboratory for Hubei New Textile Materials and Advanced Processing Technologies, School of Textile Science and Engineering, Wuhan Textile University, Wuhan, China
Contribution: Investigation (equal)
Search for more papers by this authorCorresponding Author
Xiufang Li
State Key Laboratory of New Textile Materials and Advanced Processing Technologies, Hubei International Scientific and Technological Cooperation Base of Intelligent Textile Materials & Application, Wuhan Textile University, Wuhan, China
Correspondence
Xiufang Li, State Key Laboratory of New Textile Materials and Advanced Processing Technologies, Hubei International Scientific and Technological Cooperation Base of Intelligent Textile Materials & Application, Wuhan Textile University, Wuhan 430200, China.
Email: [email protected]
Yanfei Feng and Renchuan You, State Key Laboratory for Hubei New Textile Materials and Advanced Processing Technologies, School of Textile Science and Engineering, Wuhan Textile University, Wuhan 430200, China.
Email: [email protected]; [email protected]
Contribution: Conceptualization (lead), Funding acquisition (lead), Investigation (equal), Validation (lead)
Search for more papers by this authorCorresponding Author
Yanfei Feng
State Key Laboratory for Hubei New Textile Materials and Advanced Processing Technologies, School of Textile Science and Engineering, Wuhan Textile University, Wuhan, China
Correspondence
Xiufang Li, State Key Laboratory of New Textile Materials and Advanced Processing Technologies, Hubei International Scientific and Technological Cooperation Base of Intelligent Textile Materials & Application, Wuhan Textile University, Wuhan 430200, China.
Email: [email protected]
Yanfei Feng and Renchuan You, State Key Laboratory for Hubei New Textile Materials and Advanced Processing Technologies, School of Textile Science and Engineering, Wuhan Textile University, Wuhan 430200, China.
Email: [email protected]; [email protected]
Contribution: Conceptualization (lead), Supervision (lead), Writing - original draft (lead)
Search for more papers by this authorCorresponding Author
Renchuan You
State Key Laboratory for Hubei New Textile Materials and Advanced Processing Technologies, School of Textile Science and Engineering, Wuhan Textile University, Wuhan, China
Correspondence
Xiufang Li, State Key Laboratory of New Textile Materials and Advanced Processing Technologies, Hubei International Scientific and Technological Cooperation Base of Intelligent Textile Materials & Application, Wuhan Textile University, Wuhan 430200, China.
Email: [email protected]
Yanfei Feng and Renchuan You, State Key Laboratory for Hubei New Textile Materials and Advanced Processing Technologies, School of Textile Science and Engineering, Wuhan Textile University, Wuhan 430200, China.
Email: [email protected]; [email protected]
Contribution: Conceptualization (lead), Funding acquisition (lead), Methodology (lead), Supervision (lead)
Search for more papers by this authorJiahui Xiao
State Key Laboratory for Hubei New Textile Materials and Advanced Processing Technologies, School of Textile Science and Engineering, Wuhan Textile University, Wuhan, China
Contribution: Data curation (lead), Investigation (equal), Methodology (lead)
Search for more papers by this authorYueyang Ji
State Key Laboratory for Hubei New Textile Materials and Advanced Processing Technologies, School of Textile Science and Engineering, Wuhan Textile University, Wuhan, China
Contribution: Investigation (lead)
Search for more papers by this authorZixin Gao
State Key Laboratory for Hubei New Textile Materials and Advanced Processing Technologies, School of Textile Science and Engineering, Wuhan Textile University, Wuhan, China
Contribution: Conceptualization (lead)
Search for more papers by this authorYunfeng Dai
State Key Laboratory for Hubei New Textile Materials and Advanced Processing Technologies, School of Textile Science and Engineering, Wuhan Textile University, Wuhan, China
Contribution: Investigation (equal)
Search for more papers by this authorCorresponding Author
Xiufang Li
State Key Laboratory of New Textile Materials and Advanced Processing Technologies, Hubei International Scientific and Technological Cooperation Base of Intelligent Textile Materials & Application, Wuhan Textile University, Wuhan, China
Correspondence
Xiufang Li, State Key Laboratory of New Textile Materials and Advanced Processing Technologies, Hubei International Scientific and Technological Cooperation Base of Intelligent Textile Materials & Application, Wuhan Textile University, Wuhan 430200, China.
Email: [email protected]
Yanfei Feng and Renchuan You, State Key Laboratory for Hubei New Textile Materials and Advanced Processing Technologies, School of Textile Science and Engineering, Wuhan Textile University, Wuhan 430200, China.
Email: [email protected]; [email protected]
Contribution: Conceptualization (lead), Funding acquisition (lead), Investigation (equal), Validation (lead)
Search for more papers by this authorCorresponding Author
Yanfei Feng
State Key Laboratory for Hubei New Textile Materials and Advanced Processing Technologies, School of Textile Science and Engineering, Wuhan Textile University, Wuhan, China
Correspondence
Xiufang Li, State Key Laboratory of New Textile Materials and Advanced Processing Technologies, Hubei International Scientific and Technological Cooperation Base of Intelligent Textile Materials & Application, Wuhan Textile University, Wuhan 430200, China.
Email: [email protected]
Yanfei Feng and Renchuan You, State Key Laboratory for Hubei New Textile Materials and Advanced Processing Technologies, School of Textile Science and Engineering, Wuhan Textile University, Wuhan 430200, China.
Email: [email protected]; [email protected]
Contribution: Conceptualization (lead), Supervision (lead), Writing - original draft (lead)
Search for more papers by this authorCorresponding Author
Renchuan You
State Key Laboratory for Hubei New Textile Materials and Advanced Processing Technologies, School of Textile Science and Engineering, Wuhan Textile University, Wuhan, China
Correspondence
Xiufang Li, State Key Laboratory of New Textile Materials and Advanced Processing Technologies, Hubei International Scientific and Technological Cooperation Base of Intelligent Textile Materials & Application, Wuhan Textile University, Wuhan 430200, China.
Email: [email protected]
Yanfei Feng and Renchuan You, State Key Laboratory for Hubei New Textile Materials and Advanced Processing Technologies, School of Textile Science and Engineering, Wuhan Textile University, Wuhan 430200, China.
Email: [email protected]; [email protected]
Contribution: Conceptualization (lead), Funding acquisition (lead), Methodology (lead), Supervision (lead)
Search for more papers by this authorAbstract
Natural silk fibroin nanofibers (SNF) have recently attracted great attention in the field of biomaterials due to their excellent biocompatibility, outstanding mechanical properties, and biomimetic nanostructures. However, the poor structural stability of SNF assembly in aqueous conditions remains a major obstacle to their biomedical application. In this work, SNF scaffolds with extracellular matrix-mimicking architecture and tunable properties were developed by using a small amount of konjac glucomannan (KGM) as a physical adhesive. Fourier transform infrared spectroscopy (FTIR) results revealed that KGM facilitated the formation of hydrogen bond networks between SNF as well as nanofibers/polysaccharide molecules, thereby reinforcing the interconnectivity between SNF. The water stability test showed that SNF scaffolds exhibited good structural stability in water when the mass ratio of KGM/SNF reached 2.5/100. Raising KGM content significantly enhanced the compression strength, modulus, and swelling ratio of the porous scaffold. Whereas, the nanofibrous morphology and porosity of the scaffolds were significantly sacrificed as KGM content exceeded 10% as evidenced by scanning electron microscopy (SEM) results. In vitro, cytocompatibility results also demonstrated the excellent biocompatibility of the biomimetic nanofibrous scaffolds, and the high porosity significantly enhanced cell viability. These results suggest that KGM-reinforced SNF scaffolds may serve as promising candidates for biomaterial applications.
CONFLICT OF INTEREST STATEMENT
The authors declare no conflict of interest.
Open Research
DATA AVAILABILITY STATEMENT
Data sharing is not applicable to this article as no new data were created or analyzed in this study.
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