To improve sustained and controlled drug-delivery systems, the construction of polymeric matrices with a high loading of bioactive molecules and controllable release under physiological conditions is vitally important. Renbao Gu et al. fabricate a hydrogel nanocomposite film by alternating deposition of core-shell poly[(dimethylimino)(2-hydroxy-1,3-propanedily) chloride] (PDMIHPC)-laponite nanocomposite dispersion and poly(acrylic acid) (PAA). This layer-by-layer assembly process undergoes linear growth. The cover shows a SEM cross section of the hydrogel nanocomposite film after loading with methylene blue dye (MB). The loading capacity of the film for MB is as large as 4.48 μg/cm2 per bilayer due to the introduction of core-shell PDMIHPC-laponite as a film component. This hydrogel nanocomposite film shows good pH-triggered loading-release reversibility, and could be an advanced material for applications in triggered controlled release systems. DOI: 10.1002/app.39352
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