The effect of process parameters on the size and morphology of poly(D,L-lactide-co-glycolide) micro/nanoparticles prepared by an oil in oil emulsion/solvent evaporation technique
Corresponding Author
Hamid Mahdavi
Novel Drug Delivery Systems and Biomaterial Department, Science Faculty, Iran Polymer and Petrochemical Institute, Tehran, Iran
Novel Drug Delivery Systems and Biomaterial Department, Science Faculty, Iran Polymer and Petrochemical Institute, Tehran, Iran===Search for more papers by this authorHamid Mirzadeh
Novel Drug Delivery Systems and Biomaterial Department, Science Faculty, Iran Polymer and Petrochemical Institute, Tehran, Iran
Search for more papers by this authorHamed Hamishehkar
Department of Pharmaceutical Technology, Drug Applied Research Center, Tabriz University (Medical Sciences), Tabriz, Iran
Search for more papers by this authorAhmad Jamshidi
Novel Drug Delivery Systems and Biomaterial Department, Science Faculty, Iran Polymer and Petrochemical Institute, Tehran, Iran
Search for more papers by this authorAmir Fakhari
Novel Drug Delivery Systems and Biomaterial Department, Science Faculty, Iran Polymer and Petrochemical Institute, Tehran, Iran
Search for more papers by this authorJaber Emami
School of Pharmacy and Pharmaceutical Sciences and Isfahan Pharmaceutical Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Search for more papers by this authorAbdolhossien Rouholamini Najafabadi
Aerosol Research Laboratory, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Search for more papers by this authorKambiz Gilani
Aerosol Research Laboratory, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Search for more papers by this authorMohsen Minaiyan
School of Pharmacy and Pharmaceutical Sciences and Isfahan Pharmaceutical Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Search for more papers by this authorMahnaz Najafi
Novel Drug Delivery Systems and Biomaterial Department, Science Faculty, Iran Polymer and Petrochemical Institute, Tehran, Iran
Search for more papers by this authorMaryam Tajarod
Novel Drug Delivery Systems and Biomaterial Department, Science Faculty, Iran Polymer and Petrochemical Institute, Tehran, Iran
Search for more papers by this authorAli Nokhodchi
Medway School of Pharmacy, The Universities of Kent and Greenwich, Chatham Maritime, Kent ME4 4TB, United Kingdom
Search for more papers by this authorCorresponding Author
Hamid Mahdavi
Novel Drug Delivery Systems and Biomaterial Department, Science Faculty, Iran Polymer and Petrochemical Institute, Tehran, Iran
Novel Drug Delivery Systems and Biomaterial Department, Science Faculty, Iran Polymer and Petrochemical Institute, Tehran, Iran===Search for more papers by this authorHamid Mirzadeh
Novel Drug Delivery Systems and Biomaterial Department, Science Faculty, Iran Polymer and Petrochemical Institute, Tehran, Iran
Search for more papers by this authorHamed Hamishehkar
Department of Pharmaceutical Technology, Drug Applied Research Center, Tabriz University (Medical Sciences), Tabriz, Iran
Search for more papers by this authorAhmad Jamshidi
Novel Drug Delivery Systems and Biomaterial Department, Science Faculty, Iran Polymer and Petrochemical Institute, Tehran, Iran
Search for more papers by this authorAmir Fakhari
Novel Drug Delivery Systems and Biomaterial Department, Science Faculty, Iran Polymer and Petrochemical Institute, Tehran, Iran
Search for more papers by this authorJaber Emami
School of Pharmacy and Pharmaceutical Sciences and Isfahan Pharmaceutical Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Search for more papers by this authorAbdolhossien Rouholamini Najafabadi
Aerosol Research Laboratory, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Search for more papers by this authorKambiz Gilani
Aerosol Research Laboratory, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Search for more papers by this authorMohsen Minaiyan
School of Pharmacy and Pharmaceutical Sciences and Isfahan Pharmaceutical Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Search for more papers by this authorMahnaz Najafi
Novel Drug Delivery Systems and Biomaterial Department, Science Faculty, Iran Polymer and Petrochemical Institute, Tehran, Iran
Search for more papers by this authorMaryam Tajarod
Novel Drug Delivery Systems and Biomaterial Department, Science Faculty, Iran Polymer and Petrochemical Institute, Tehran, Iran
Search for more papers by this authorAli Nokhodchi
Medway School of Pharmacy, The Universities of Kent and Greenwich, Chatham Maritime, Kent ME4 4TB, United Kingdom
Search for more papers by this authorAbstract
For the past few decades, there has been a considerable research interest in the area of biodegradable polymeric micro- and nanoparticles for tissue engineering, regenerative medicine, implants, stents, medical devices, and drug delivery systems. Poly(D,L-lactide-co-glycolide) (PLGA) is well-known by its safety in biomedical preparations which has been approved for human use by the FDA. The goal of this study was to evaluate the influence of process parameters on size characteristics of PLGA microparticles prepared by oil in oil (o/o) solvent evaporation technique. This method has been introduced as one of the most appropriate methods for hydrophilic agents. Scanning electron microscopy showed that prepared particles were spherical with smooth surface without aggregation. Particle size varied from 570 nm to 29 μm in different experimental conditions. Stirring speed, polymer concentration, impeller type, and dropping size had a significant effect on the particle size. The polydispersity index of particles showed a strong relationship with the surfactant concentration, impeller type, and dropping size. It was concluded that increasing in temperature up to 50°C or changing in dropping rate has a little effect on reducing the size of PLGA particles. The residual solvent content in the final suspension was less than 0.1 ppm that is in appropriate range for biomedical application. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
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