Volume 110, Issue 4 pp. 2058-2062

Preparation and characterization of a novel series of amphiphilic phospholipids compounds

Hui Yu

State Key Lab for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 200051, China

Cancer Institute of Shanghai Jiao Tong University, Shanghai 200032, China

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Xiaohua Gu,

Xiaohua Gu

State Key Lab for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 200051, China

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Xuelian Qi,

Xuelian Qi

Cancer Institute of Shanghai Jiao Tong University, Shanghai 200032, China

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Xiaoyan Chen,

Xiaoyan Chen

Cancer Institute of Shanghai Jiao Tong University, Shanghai 200032, China

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Xinyuan Shen,

Corresponding Author

Xinyuan Shen

[email protected]

State Key Lab for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 200051, China

Xinyuan Shen, Cancer Institute of Shanghai Jiao Tong University, Shanghai 200032, China===

Yourong Duan, State Key Lab for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 200051, China===

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Yourong Duan,

Corresponding Author

Yourong Duan

[email protected]

Cancer Institute of Shanghai Jiao Tong University, Shanghai 200032, China

Xinyuan Shen, Cancer Institute of Shanghai Jiao Tong University, Shanghai 200032, China===

Yourong Duan, State Key Lab for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 200051, China===

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Hui Yu,

Hui Yu

State Key Lab for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 200051, China

Cancer Institute of Shanghai Jiao Tong University, Shanghai 200032, China

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Xiaohua Gu,

Xiaohua Gu

State Key Lab for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 200051, China

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Xuelian Qi,

Xuelian Qi

Cancer Institute of Shanghai Jiao Tong University, Shanghai 200032, China

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Xiaoyan Chen,

Xiaoyan Chen

Cancer Institute of Shanghai Jiao Tong University, Shanghai 200032, China

Search for more papers by this author

Xinyuan Shen,

Corresponding Author

Xinyuan Shen

[email protected]

State Key Lab for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 200051, China

Xinyuan Shen, Cancer Institute of Shanghai Jiao Tong University, Shanghai 200032, China===

Yourong Duan, State Key Lab for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 200051, China===

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Yourong Duan,

Corresponding Author

Yourong Duan

[email protected]

Cancer Institute of Shanghai Jiao Tong University, Shanghai 200032, China

Xinyuan Shen, Cancer Institute of Shanghai Jiao Tong University, Shanghai 200032, China===

Yourong Duan, State Key Lab for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 200051, China===

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First published: 07 August 2008

https://doi.org/10.1002/app.28694

Citations: 1

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Abstract

For application of phospholipids compounds in drug permeation field, a novel series of amphiphilic phospholipids compounds containing different aliphatic chains as the hydrophobic tail groups and phosphorylcholine as the hydrophilic head groups were synthesized in three steps: preparation of hydroxyalkyl methacrylate by the reaction of various aliphatic chain diols with α-methacryloyl chloride; preparation of 2-(2-oxo-1,3,2-dioxaphospholoyloxy)alkyl methacrylate by the reaction of hydroxyalkyl methacrylate with 2-chloro-2-oxo-1,3,2-dioxaphospholane; preparation of the amphiphilic phospholipids compounds by the ring-opening reaction of 2-(2-oxo-1,3,2-dioxaphospholoyloxy)alkyl methacrylate in the presence of trimethylamine. The chemical structure of the amphiphilic phospholipids compounds were supported by Fourier transform infrared spectroscopy and ¹H NMR. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008

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Volume110, Issue4

15 November 2008

Pages 2058-2062

Preparation and characterization of a novel series of amphiphilic phospholipids compounds

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Preparation and characterization of a novel series of amphiphilic phospholipids compounds

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