Nickel Complexes Bearing SNN and SS Donor Atom Ligands: Synthesis, Structural Characterization and Biological activity
Corresponding Author
Ahmed B.M. Ibrahim
Department of Chemistry, Faculty of Science, Assiut University, Assiut, 71515 Egypt
Correspondence
Ahmed B.M. Ibrahim, Department of Chemistry, Faculty of Science, Assiut University, Assiut 71515, Egypt.
Email: [email protected]
Search for more papers by this authorMicheal K. Farh
Department of Chemistry, Faculty of Science, Assiut University, Assiut, 71515 Egypt
Search for more papers by this authorIsabel Cordeiro Santos
Centro de Ciências e Tecnologias Nucleares, Instituto Superior Técnico, Universidade de Lisboa, Estrada Nacional 10 (km 139,7), 2695-066, Bobadela LRS, Portugal
Search for more papers by this authorAntónio Paulo
Centro de Ciências e Tecnologias Nucleares, Instituto Superior Técnico, Universidade de Lisboa, Estrada Nacional 10 (km 139,7), 2695-066, Bobadela LRS, Portugal
Search for more papers by this authorCorresponding Author
Ahmed B.M. Ibrahim
Department of Chemistry, Faculty of Science, Assiut University, Assiut, 71515 Egypt
Correspondence
Ahmed B.M. Ibrahim, Department of Chemistry, Faculty of Science, Assiut University, Assiut 71515, Egypt.
Email: [email protected]
Search for more papers by this authorMicheal K. Farh
Department of Chemistry, Faculty of Science, Assiut University, Assiut, 71515 Egypt
Search for more papers by this authorIsabel Cordeiro Santos
Centro de Ciências e Tecnologias Nucleares, Instituto Superior Técnico, Universidade de Lisboa, Estrada Nacional 10 (km 139,7), 2695-066, Bobadela LRS, Portugal
Search for more papers by this authorAntónio Paulo
Centro de Ciências e Tecnologias Nucleares, Instituto Superior Técnico, Universidade de Lisboa, Estrada Nacional 10 (km 139,7), 2695-066, Bobadela LRS, Portugal
Search for more papers by this authorAbstract
Based on a tridentate thiosemicarbazone ligand {HL = 4-(2,4-dimethylphenyl)-1-((pyridin-2-yl)methylene)thiosemicarbazide}, the nickel complexes [NiCl(L)] 1, [Ni(L)(diEtdtc)(H2O)] 2 and [Ni(L)(pipdtc)(H2O)] 3 were prepared {NadiEtdtc = sodium diethyldithiocarbamate and Napipdtc = sodium piperidine dithiocarbamate} and their structures were elucidated according to their elemental analyses, solution conductivities, magnetic moments and spectroscopic (IR and electronic) data. X-ray single crystal studies have confirmed the structure of 1 as a square planar complex in which each nickel atom is linked to three (two nitrogen and one sulfur) atoms from the thiosemicarbazone ligand and a chlorine atom to ensure the complex neutrality. Moreover, the asymmetric unit cell of the complex was found to consist of two independent complex molecules of slightly different conformations (A&B). The complexes, especially the binary one, displayed high bactericidal activities that, in several instances, were comparable to or higher than those of the chloramphenicol standard.
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