Gabriele Laudadio
Graphical Abstract
“A turning point in my career was when I realized that I was running a marathon, not a 100-meter dash… When I was a kid I wanted to be an inventor – and I think I did not end up too far from that...” Find out more about Gabriele Laudadio in his Introducing… Profile.
Gabriele Laudadio
The author presented on this page has published his first article as a submitting corresponding author in Angewandte Chemie:
“An Automated Electrochemical Flow Platform to Accelerate Library Synthesis and Reaction Optimization”: E. Rial-Rodríguez, J. D. Williams, D. Cantillo, T. Fuchß, A. Sommer, H.-M. Eggenweiler, C. O. Kappe, G. Laudadio, Angew. Chem. Int. Ed. 2024, 63, e202412045.
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Position, Location:
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Principal Investigator (University Assistant), University of Graz (Austria)
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Homepage:
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ORCID:
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Education:
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2016 M.Sc. Organic Chemistry, University of Pisa (Italy)
2020 Ph.D. in Chemistry with Timothy Noël, Eindhoven University of Technology, (The Netherlands)
2021 Postdoctoral researcher with Phil S. Baran, The Scripps Research Institute, La Jolla CA (USA)
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Research:
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Organic electrosynthesis, electrocatalysis, flow chemistry
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Hobbies:
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Studying philosophy, swimming, playing soccer?
My science “heroes” are Sir D. H. R. Barton, Maria Skłodowska-Curie, and Nikola Tesla.
The greatest scientific advance of the next decade will be nuclear fusion power.
The most exciting thing about my research is providing new technological solutions to longstanding synthetic problems.
I chose my current career path because it allows me to express my creativity through my ideas without compromise.
A turning point in my career was when I realized that I was running a marathon, not a 100-meter dash.
My favorite name reaction is the Wittig reaction.
I advise my students to approach their research with excitement and curiosity.
The most important quality of a mentor is empathy, which stems from effective communication.
The best advice I have ever been given is to be resilient and believe in what I am doing.
I lose track of time when I am designing schemes for my papers.
When I was a kid I wanted to be an inventor – and I think I did not end up too far from that.
A good day at work starts with a good espresso.
My most important role models are my grandparents because they taught me that to be proud of what you build, you have to invest time and energy in it.
My favorite place on earth is the Aegadian Islands.
My favorite piece of music is Vivaldi's “Storm”.
Behind the Science
In the context of medicinal chemistry, there is always a pressing demand for innovative systems to accelerate molecule diversification. Electrochemistry is an appealing tool but has traditionally been hindered by miniaturization challenges, as it is difficult to create an electrochemical equivalent to a well-plate. In collaboration with Merck KGaA, we addressed this challenge by developing a novel slug-based flow platform that effectively overcomes these electrochemical engineering hurdles. This allowed us to generate libraries of compounds related to E3 ligase binders using a challenging electrocatalytic C–N cross-coupling. We hope that our approach will pave the way for broader applications of electrochemistry in medicinal chemistry.
