Volume 58, Issue 22 p. 7495
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Inside Back Cover: Nickel-Catalyzed Asymmetric Hydrogenation of N-Sulfonyl Imines (Angew. Chem. Int. Ed. 22/2019)

Bowen Li

Bowen Li

Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240 P. R. China

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Dr. Jianzhong Chen

Dr. Jianzhong Chen

Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240 P. R. China

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Dr. Zhenfeng Zhang

Dr. Zhenfeng Zhang

Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240 P. R. China

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Prof. Ilya D. Gridnev

Prof. Ilya D. Gridnev

Department of Chemistry, Graduate School of Science, Tohoku University, Sendai, 9808578 Japan

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Prof. Wanbin Zhang

Corresponding Author

Prof. Wanbin Zhang

Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240 P. R. China

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First published: 10 May 2019
Citations: 3

Graphical Abstract

The first nickel-catalyzed asymmetric hydrogenation of N-sulfonyl imines using H2 gas as a hydrogen source has been realized with high catalytic activity (S/C up to 10 500) and excellent enantioselectivity (up to 99.7% ee). Compared with other transition-metal catalysts (Rh, Ru, Ir, Pd, etc.), earth-abundant and inexpensive Ni catalysts are preferable for the preparation of chiral amines on an industrial scale. Details of the study are presented by W. Zhang et al. in their Communication on page 7329.

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