Bioinspired Artificial Nanodecoys for Hepatitis B Virus
Dr. Xuan Liu
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, 361102 China
These authors contributed equally to this work.
Search for more papers by this authorDr. Lunzhi Yuan
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & National Institute of Diagnostics and Vaccine Development in Infectious Disease, School of Public Health and School of Life Science, Xiamen University, 361102 China
These authors contributed equally to this work.
Search for more papers by this authorLiang Zhang
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & National Institute of Diagnostics and Vaccine Development in Infectious Disease, School of Public Health and School of Life Science, Xiamen University, 361102 China
Search for more papers by this authorYalin Mu
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, 361102 China
Search for more papers by this authorXiaoling Li
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & National Institute of Diagnostics and Vaccine Development in Infectious Disease, School of Public Health and School of Life Science, Xiamen University, 361102 China
Search for more papers by this authorDr. Chao Liu
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, 361102 China
Search for more papers by this authorDr. Peng Lv
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, 361102 China
Search for more papers by this authorDr. Yali Zhang
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & National Institute of Diagnostics and Vaccine Development in Infectious Disease, School of Public Health and School of Life Science, Xiamen University, 361102 China
Search for more papers by this authorProf. Tong Cheng
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & National Institute of Diagnostics and Vaccine Development in Infectious Disease, School of Public Health and School of Life Science, Xiamen University, 361102 China
Search for more papers by this authorCorresponding Author
Prof. Quan Yuan
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & National Institute of Diagnostics and Vaccine Development in Infectious Disease, School of Public Health and School of Life Science, Xiamen University, 361102 China
Search for more papers by this authorProf. Ningshao Xia
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & National Institute of Diagnostics and Vaccine Development in Infectious Disease, School of Public Health and School of Life Science, Xiamen University, 361102 China
Search for more papers by this authorDr. Xiaoyuan Chen
Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892 USA
Search for more papers by this authorCorresponding Author
Prof. Gang Liu
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, 361102 China
State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, Xiamen University, 361102 China
Search for more papers by this authorDr. Xuan Liu
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, 361102 China
These authors contributed equally to this work.
Search for more papers by this authorDr. Lunzhi Yuan
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & National Institute of Diagnostics and Vaccine Development in Infectious Disease, School of Public Health and School of Life Science, Xiamen University, 361102 China
These authors contributed equally to this work.
Search for more papers by this authorLiang Zhang
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & National Institute of Diagnostics and Vaccine Development in Infectious Disease, School of Public Health and School of Life Science, Xiamen University, 361102 China
Search for more papers by this authorYalin Mu
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, 361102 China
Search for more papers by this authorXiaoling Li
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & National Institute of Diagnostics and Vaccine Development in Infectious Disease, School of Public Health and School of Life Science, Xiamen University, 361102 China
Search for more papers by this authorDr. Chao Liu
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, 361102 China
Search for more papers by this authorDr. Peng Lv
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, 361102 China
Search for more papers by this authorDr. Yali Zhang
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & National Institute of Diagnostics and Vaccine Development in Infectious Disease, School of Public Health and School of Life Science, Xiamen University, 361102 China
Search for more papers by this authorProf. Tong Cheng
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & National Institute of Diagnostics and Vaccine Development in Infectious Disease, School of Public Health and School of Life Science, Xiamen University, 361102 China
Search for more papers by this authorCorresponding Author
Prof. Quan Yuan
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & National Institute of Diagnostics and Vaccine Development in Infectious Disease, School of Public Health and School of Life Science, Xiamen University, 361102 China
Search for more papers by this authorProf. Ningshao Xia
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & National Institute of Diagnostics and Vaccine Development in Infectious Disease, School of Public Health and School of Life Science, Xiamen University, 361102 China
Search for more papers by this authorDr. Xiaoyuan Chen
Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892 USA
Search for more papers by this authorCorresponding Author
Prof. Gang Liu
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, 361102 China
State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, Xiamen University, 361102 China
Search for more papers by this authorGraphical Abstract
Hitting hepatitis: A facile and bioinspired strategy is presented for fabricating a class of nanomimics that over-express Hepatitis B virus (HBV) receptor by a natural biosynthetic procedure to act against HBV infection.
Abstract
A facile route is presented for fabricating a new class of nanomimics that overexpress hepatitis B virus (HBV) receptor by a natural biosynthetic procedure against HBV infection. A nine-transmembrane HBV-specific receptor, human sodium taurocholate co-transporting polypeptide (hNTCP), was engineered to naturally immobilize it onto the cellular surface and subsequently trigger the budding of hNTCP-anchoring membrane vesicles (hNTCP-MVs) that favor the HBV virion. hNTCP-MVs could rapidly block HBV infection in cell models. Furthermore, hNTCP-MVs treatment could effectively prevent viral infection, spreading, and replication in a human-liver-chimeric mouse model of HBV infection. Our findings demonstrate the receptor-mediated antiviral effect of hNTCP-MVs to trick HBV and offer novel opportunities for further development of antiviral strategies in nanomedicine.
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