Review
On the Development of Electron Cryo-Microscopy (Nobel Lecture)†
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Copyright© The Nobel Foundation 2017. We thank the Nobel Foundation, Stockholm, for permission to print this lecture.
Graphical Abstract
An electron microscope must operate under vacuum which means that any observed biological specimen must be dry. When water is removed, however, the molecules stick to each other. J. Dubochet describes in his Nobel lecture the solution to this dilemma that paved the way to electron-cryo microscopy: suspension of the specimen in vitrifying water.
