Volume 57, Issue 13 p. 3265
Cover Picture
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Cover Picture: Epoxides as Alkylating Reagents for the Catellani Reaction (Angew. Chem. Int. Ed. 13/2018)

Dr. Hong-Gang Cheng

Dr. Hong-Gang Cheng

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072 China

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Chenggui Wu

Chenggui Wu

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072 China

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Han Chen

Han Chen

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072 China

These authors contributed equally.

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Ruiming Chen

Ruiming Chen

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072 China

These authors contributed equally.

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Guangyin Qian

Guangyin Qian

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072 China

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Zhi Geng

Zhi Geng

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072 China

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Qiang Wei

Qiang Wei

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072 China

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Yuanyuan Xia

Yuanyuan Xia

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072 China

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Jingyang Zhang

Jingyang Zhang

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072 China

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Yuming Zhang

Yuming Zhang

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072 China

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Prof. Dr. Qianghui Zhou

Corresponding Author

Prof. Dr. Qianghui Zhou

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072 China

The Institute for Advanced Studies, Wuhan University, Wuhan, 430072 China

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First published: 26 February 2018

Graphical Abstract

Epoxides are highly challenging alkylating reagents for the Catellani reaction. In their Communication on page 3444, Q. Zhou and co-workers report a cooperative catalytic system comprising of a PdII/XPhos complex and the potassium salt of 5-norbornene-2-carboxylic acid to enable the use of epoxides as alkylating reagents in the Catellani reaction. The picture shows the key elements of this novel transformation, with representative buildings of Wuhan University in the background. Cover design by Jun Deng, Wuhan University.

Epoxides are highly challenging alkylating reagents for the Catellani reaction. In their Communication on page 3444, Q. Zhou and co-workers report a cooperative catalytic system comprising of a PdII/XPhos complex and the potassium salt of 5-norbornene-2-carboxylic acid to enable the use of epoxides as alkylating reagents in the Catellani reaction. The picture shows the key elements of this novel transformation, with representative buildings of Wuhan University in the background. Cover design by Jun Deng, Wuhan University.

Nitrogen-Based Lewis Acids

D. W. Stephan and co-workers show in their Communication on page 3322 ff. that a cyclic (alkyl)(amino) nitrenium featuring a cationic nitrogen atom has enhanced electrophilicity.

Reaction Kinetics

Chemicals can be released to a solution reaction from a piece of ice, as described by B. Ge, L.-M. Liu, H. Wu et al. in their Communication on page 3354 ff. By this simple ice-melting process, nuclei formation and growth can be successfully suppressed.

Natural Products

In their Communication on page 3386 ff., J. Xu et al. report the first total synthesis of astellatol, which was first discovered three decades ago. The synthesis is enantiospecific and access to the bicyclic core is efficient.

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